Curated Optogenetic Publication Database

Search precisely and efficiently by using the advantage of the hand-assigned publication tags that allow you to search for papers involving a specific trait, e.g. a particular optogenetic switch or a host organism.

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LOVTRAP: an optogenetic system for photoinduced protein dissociation.

blue LOVTRAP HEK293 HeLa in vitro Control of cytoskeleton / cell motility / cell shape
Nat Methods, 18 Jul 2016 DOI: 10.1038/nmeth.3926 Link to full text
Abstract: LOVTRAP is an optogenetic approach for reversible light-induced protein dissociation using protein A fragments that bind to the LOV domain only in the dark, with tunable kinetics and a >150-fold change in the dissociation constant (Kd). By reversibly sequestering proteins at mitochondria, we precisely modulated the proteins' access to the cell edge, demonstrating a naturally occurring 3-mHz cell-edge oscillation driven by interactions of Vav2, Rac1, and PI3K proteins.
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