Optogenetic Switches

UV Violet Blue Cyan Green Yellow Red Far Red
300 nm 400 nm 500 nm 600 nm 700 nm

UV receptors

Switch name (# of implementations)
Mode of action
UVR8/COP1 (4)
heterodimerization
UVR8/UVR8 (3)
homodimerization, dissociation

Cyanobacteriochromes

Switch name (# of implementations)
Mode of action
CcaS/CcaR (15)
gene expression
cPAC (1)
cAMP production
UirS/UirR (2)
gene expression

BLUF domains

Switch name (# of implementations)
Mode of action
PixD/PixE (2)
heterooligomerization, dissociation
BlrP1 (1)
c-di-GMP hydrolysis
bPAC (BlaC) (15)
cAMP production
BlgC (2)
cGMP production
EB1 (4)
c-di-GMP hydrolysis
euPAC (6)
cAMP production
NgPAC (1)
cAMP production
OaPAC (1)
cAMP production

LOV domains

Switch name (# of implementations)
Mode of action
AsLOV2 (70)
intramolecular conformational change
iLID (31)
heterodimerization
LOVTRAP (11)
heterodimerization, dissociation
TULIP (19)
heterodimerization
AtLOV2 (7)
intramolecular conformational change
BcLOV4 (2)
intramolecular conformational change, membrane recruitment
CrLOV1 (2)
? Add information
EL222 (14)
homodimerization, DNA binding
FKF1/GI (6)
heterodimerization
NcWC1-LOV (2)
? Add information
RsLOV (3)
homodimerization, dissociation
VfAU1-LOV (6)
homodimerization
VVD (26)
homodimerization
Magnets (14)
heterodimerization
YtvA (11)
homodimerization
miniSOG (10)
singlet oxygen (ROS) production
mPAC (2)
cAMP production

Cryptochromes

Switch name (# of implementations)
Mode of action
CRY2/CIB1 (112)
heterodimerization
CRY2/CRY2 (32)
homooligomerization
CRY2clust (1)
homooligomerization
CRY2olig (19)
homooligomerization

Fluorescent proteins

Switch name (# of implementations)
Mode of action
Dronpa145K/N (3)
heterodimerization, dissociation
Dronpa145N (4)
homotetramerization, dissociation
pdDronpa1 (2)
homodimerization, dissociation
PYP (4)
intramolecular conformational change

Opsins

Switch name (# of implementations)
Mode of action
BeCyclOp (BeGC1) (3)
cGMP production

Cobalamin-binding domains

Switch name (# of implementations)
Mode of action
MxCBD (1)
homotetramerization, dissociation
TtCBD (3)
homotetramerization, dissociation

Phytochromes

Switch name (# of implementations)
Mode of action
BphP1/PpsR2 (4)
heterodimerization
BphP1/Q-PAS1 (4)
heterodimerization
Cph1 (11)
homodimerization
DrBphP (1)
homodimerization, dissociation
PhyA/FHY1 & PhyA/FHL (2)
heterodimerization
PhyB/PIF3 & PhyB/PIF6 (52)
heterodimerization
BphG (2)
c-di-GMP production
BphS (10)
c-di-GMP production
IlaC (1)
cAMP production
LAPD (2)
cGMP/cAMP hydrolysis