Optogenetic Switches

UV Violet Blue Cyan Green Yellow Red Far Red
300 nm 400 nm 500 nm 600 nm 700 nm

UV receptors

Switch name (# of implementations)
Mode of action
UVR8/COP1 (4)
heterodimerization
UVR8/UVR8 (2)
homodimerization, dissociation

Cyanobacteriochromes

Switch name (# of implementations)
Mode of action
CcaS/CcaR (13)
gene expression
cPAC (1)
cAMP production
UirS/UirR (2)
gene expression

BLUF domains

Switch name (# of implementations)
Mode of action
PixD/PixE (1)
heterooligomerization, dissociation
BlrP1 (1)
c-di-GMP hydrolysis
bPAC (BlaC) (13)
cAMP production
BlgC (2)
cGMP production
EB1 (3)
c-di-GMP hydrolysis
euPAC (6)
cAMP production
NgPAC (1)
cAMP production
OaPAC (1)
cAMP production

LOV domains

Switch name (# of implementations)
Mode of action
AsLOV2 (55)
intramolecular conformational change
iLID (21)
heterodimerization
LOVTRAP (7)
heterodimerization, dissociation
TULIP (15)
heterodimerization
AtLOV2 (6)
intramolecular conformational change
CrLOV1 (1)
? Add information
EL222 (10)
homodimerization, DNA binding
FKF1/GI (6)
heterodimerization
NcWC1-LOV (2)
? Add information
RsLOV (2)
homodimerization, dissociation
VfAU1-LOV (3)
homodimerization
VVD (22)
homodimerization
Magnets (12)
heterodimerization
YtvA (9)
homodimerization
miniSOG (10)
singlet oxygen (ROS) production
mPAC (2)
cAMP production

Cryptochromes

Switch name (# of implementations)
Mode of action
CRY2/CIB1 (91)
heterodimerization
CRY2/CRY2 (22)
homooligomerization
CRY2clust (1)
homooligomerization
CRY2olig (10)
homooligomerization

Fluorescent proteins

Switch name (# of implementations)
Mode of action
Dronpa145K/N (2)
heterodimerization, dissociation
Dronpa145N (3)
homotetramerization, dissociation
pdDronpa1 (2)
homodimerization, dissociation
PYP (3)
intramolecular conformational change

Opsins

Switch name (# of implementations)
Mode of action
BeCyclOp (BeGC1) (3)
cGMP production

Cobalamin-binding domains

Switch name (# of implementations)
Mode of action
MxCBD (1)
homotetramerization, dissociation
TtCBD (3)
homotetramerization, dissociation

Phytochromes

Switch name (# of implementations)
Mode of action
BphP1/PpsR2 (4)
heterodimerization
BphP1/Q-PAS1 (4)
heterodimerization
Cph1 (7)
homodimerization
PhyA/FHY1 & PhyA/FHL (2)
heterodimerization
PhyB/PIF3 & PhyB/PIF6 (45)
heterodimerization
BphG (2)
c-di-GMP production
BphS (7)
c-di-GMP production
IlaC (1)
cAMP production
LAPD (1)
cGMP/cAMP hydrolysis