Optogenetic Switches

UV Violet Blue Cyan Green Yellow Red Far Red
300 nm 400 nm 500 nm 600 nm 700 nm

UV receptors

Switch name (# of implementations)
Mode of action
UVR8/COP1 (3)
heterodimerization
UVR8/UVR8 (2)
homodimerization, dissociation

Cyanobacteriochromes

Switch name (# of implementations)
Mode of action
CcaS/CcaR (13)
gene expression
UirS/UirR (2)
gene expression

BLUF domains

Switch name (# of implementations)
Mode of action
bPAC (BlaC) (10)
cAMP production
BlgC (2)
cGMP production
EB1 (3)
c-di-GMP hydrolysis
euPAC (6)
cAMP production
NgPAC (1)
cAMP production
OaPAC (1)
cAMP production

LOV domains

Switch name (# of implementations)
Mode of action
AsLOV2 (44)
intramolecular conformational change
iLID (11)
heterodimerization
LOVTRAP (3)
heterodimerization, dissociation
TULIP (10)
heterodimerization
AtLOV2 (6)
intramolecular conformational change
CrLOV1 (1)
? Add information
EL222 (5)
homodimerization, DNA binding
FKF1/GI (5)
heterodimerization
NcWC1-LOV (1)
? Add information
RsLOV (2)
homodimerization, dissociation
VfAU1-LOV (3)
homodimerization
VVD (18)
homodimerization
Magnets (10)
heterodimerization
YtvA (6)
homodimerization
miniSOG (7)
singlet oxygen (ROS) production
mPAC (2)
cAMP production

Cryptochromes

Switch name (# of implementations)
Mode of action
CRY2/CIB1 (74)
heterodimerization
CRY2/CRY2 (19)
homooligomerization
CRY2clust (1)
homooligomerization
CRY2olig (6)
homooligomerization

Fluorescent proteins

Switch name (# of implementations)
Mode of action
Dronpa145K/N (2)
heterodimerization, dissociation
Dronpa145N (3)
homotetramerization, dissociation
pdDronpa1 (2)
homodimerization, dissociation
PYP (2)
intramolecular conformational change

Opsins

Switch name (# of implementations)
Mode of action
BeCyclOp (BeGC1) (2)
cGMP production

Cobalamin-binding domains

Switch name (# of implementations)
Mode of action
MxCBD (1)
homotetramerization, dissociation
TtCBD (2)
homotetramerization, dissociation

Phytochromes

Switch name (# of implementations)
Mode of action
BphP1/PpsR2 (3)
heterodimerization
Cph1 (7)
homodimerization
PhyA/FHY1 & PhyA/FHL (2)
heterodimerization
PhyB/PIF3 & PhyB/PIF6 (36)
heterodimerization
BphG (1)
c-di-GMP production
BphS (5)
c-di-GMP production
IlaC (1)
cAMP production
LAPD (1)
cGMP/cAMP hydrolysis