LOVTRAP

Photoreceptor AsLOV2
Binding partner Zdk
Cofactor FMN
Source organism Avena sativa
Mode of action heterodimerization, dissociation
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds to minutes (variants available)
Crystal structure of the LOVTRAP heterodimer, with Zdk variant Zdk1. (PDB ID: 5EFW)

Related original publications

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  1. ESCRT-mediated phagophore sealing during mitophagy. Autophagy, 2019
  2. Ran GTPase regulates non-centrosomal microtubule nucleation and is transported by actin waves towards the neurite tip. bioRxiv, 2019
  3. Optogenetic downregulation of protein levels with an ultrasensitive switch. ACS Synth Biol, 2019
  4. Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling. Elife, 2019
  5. Luciferase-LOV BRET enables versatile and specific transcriptional readout of cellular protein-protein interactions. Elife, 2019
  6. Optogenetic control reveals differential promoter interpretation of transcription factor nuclear translocation dynamics. bioRxiv, 2019
  7. Direct multiplex imaging and optogenetics of Rho GTPases enabled by near-infrared FRET. Nat Chem Biol, 2018
  8. Rewiring Calcium Signaling for Precise Transcriptional Reprogramming. ACS Synth Biol, 2018
  9. Light-dependent cytoplasmic recruitment enhances the dynamic range of a nuclear import photoswitch. Chembiochem, 2018
  10. Local control of intracellular microtubule dynamics by EB1 photodissociation. Nat Cell Biol, 2018
  11. LOVTRAP: A Versatile Method to Control Protein Function with Light. Curr Protoc Cell Biol, 2016
  12. LOVTRAP: an optogenetic system for photoinduced protein dissociation. Nat Methods, 2016