LOVTRAP

Photoreceptor AsLOV2
Binding partner Zdk
Cofactor FMN
Source organism Avena sativa
Mode of action heterodimerization, dissociation
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds to minutes (variants available)
Crystal structure of the LOVTRAP heterodimer, with Zdk variant Zdk1. (PDB ID: 5EFW)

Related original publications

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  1. Rewiring Calcium Signaling for Precise Transcriptional Reprogramming. ACS Synth Biol, 2018
  2. Light-dependent cytoplasmic recruitment enhances the dynamic range of a nuclear import photoswitch. Chembiochem, 2018
  3. Local control of intracellular microtubule dynamics by EB1 photodissociation. Nat Cell Biol, 2018
  4. LOVTRAP: A Versatile Method to Control Protein Function with Light. Curr Protoc Cell Biol, 2016
  5. LOVTRAP: an optogenetic system for photoinduced protein dissociation. Nat Methods, 2016