Platform on Molecular Optogenetics

OptoBase is an annotated database, which aims to cover all existing not ion-flux based optogenetic switches and publications. It is meant for both expert optogeneticists, to easily keep track of the field, as well as for all researchers who find optogenetics inviting as a powerful tool to address their biological questions of interest.

Cite as: K. Kolar et al.: OptoBase: A Web Platform for Molecular Optogenetics. ACS Synth. Biol. 2018, DOI: 10.1021/acssynbio.8b00120

News & Updates (see all entries)

Feb. 04, 2021 | Research Highlights in January

Paper of the Month January: Liquid-liquid phase separation of light-inducible transcription factors increases transcription activation in mammalian cells and mice.
Featured Paper: Learn more about optogenetically-controlled phase separation. Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets.

Jan. 04, 2021 | The OptoBase-Team wishes everyone a happy and healthy new year!

Research Highlights in December

Paper of the Month December: Engineering an Optogenetic CRISPRi Platform for Improved Chemical Production.
Featured Paper: Learn more about optogenetically-controlled chemical production. Optogenetic regulation of engineered cellular metabolism for microbial chemical production.

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Optogenetic Switches

(see the extended overview of the switches)

Generally applicable With a predefined function

Click on a switch for additional information.

Fluorescent proteins

PhoCl

BLUF domains

PixD/PixE

LOV domains

AsLOV2 LOVTRAP iLID TULIP AtLOV2 BcLOV4 CrLOV1

EL222 FKF1/GI NcWC1-LOV RsLOV VfAU1-LOV VVD Magnets

YtvA PtAU1-LOV

Phytochromes

BphP1/PpsR2 BphP1/Q-PAS1

UV Violet Blue Cyan Green Yellow Red Far Red

300 nm 400 nm 500 nm 600 nm 700 nm

UV receptors

UVR8/COP1 UVR8/UVR8

Cryptochromes

CRY2/CIB1 CRY2/CRY2 CRY2clust CRY2olig

Fluorescent proteins

PYP

Fluorescent proteins

Dronpa145K/N Dronpa145N pdDronpa1

Cobalamin-binding domains

MxCBD TtCBD

Cyanobacteriochromes

Am1_c0023g2/BAm_green

Phytochromes

Cph1 DrBphP PhyA/FHY1 & PhyA/FHL PhyB/PIF3 & PhyB/PIF6

Cyanobacteriochromes

Am1_c0023g2/BAm_red