Platform on Molecular Optogenetics

OptoBase is an annotated database, which aims to cover all existing non-opsin-based optogenetic switches and publications. It is meant for both expert optogeneticists, to easily keep track of the field, as well as for all researchers who find optogenetics inviting as a powerful tool to address their biological questions of interest.

Cite as: K. Kolar et al.: OptoBase: A Web Platform for Molecular Optogenetics. ACS Synth. Biol. 2018, DOI: 10.1021/acssynbio.8b00120

News & Updates (see all entries)
July 04, 2024 | Research Highlights in June

Optogenetic switches responding to different wavelengths can be combined to construct multiplexed optogenetic circuits. Such applications can be found on OptoBase using the search term "Multichromatic".

Paper of the Month June: Exploring plant-derived phytochrome chaperone proteins for light-switchable transcriptional regulation in mammals.

Featured Paper: Leveraging the histidine kinase-phosphatase duality to sculpt two-component signaling.

Optogenetic Switches

(see the extended overview of the switches)

Click on a switch for additional information.

UV Violet Blue Cyan Green Yellow Red Far Red
300 nm 400 nm 500 nm 600 nm 700 nm

UV receptors

UVR8/COP1 UVR8/UVR8

Fluorescent proteins

PYP

Fluorescent proteins

Dronpa145K/N Dronpa145N pdDronpa1

Cobalamin-binding domains

MxCBD TtCBD

Cyanobacteriochromes

Am1_c0023g2/BAm_green