Platform on Molecular Optogenetics

OptoBase is an annotated database, which aims to cover all existing non-opsin-based optogenetic switches and publications. It is meant for both expert optogeneticists, to easily keep track of the field, as well as for all researchers who find optogenetics inviting as a powerful tool to address their biological questions of interest.

Cite as: K. Kolar et al.: OptoBase: A Web Platform for Molecular Optogenetics. ACS Synth. Biol. 2018, DOI: 10.1021/acssynbio.8b00120

News & Updates (see all entries)
July 04, 2022 | Research Highlights in June

Paper of the Month June: Development of the MagRed (DrBphP/Aff6_V18FΔN) switch: A red light-responsive photoswitch for deep tissue optogenetics.

Featured Paper: First application of the DrBphP switch: Neurotrophin receptor tyrosine kinases regulated with near-infrared light.

May 06, 2022 | Research Highlights in April

Using bioluminescence to activate optogenetic switches and for communication between cells: 

Paper of the Month April: Synthetic cells with self-activating optogenetic proteins communicate with natural cells.

Featured Paper: Cell to Cell Signaling through Light in Artificial Cell Communities: Glowing Predator Lures Prey.

Optogenetic Switches

(see the extended overview of the switches)

Click on a switch for additional information.

UV Violet Blue Cyan Green Yellow Red Far Red
300 nm 400 nm 500 nm 600 nm 700 nm

UV receptors


Fluorescent proteins


Fluorescent proteins

Dronpa145K/N Dronpa145N pdDronpa1

Cobalamin-binding domains