CRY2olig

Photoreceptor CRY2olig
Binding partner /
Cofactor FAD
Source organism Arabidopsis thaliana
Mode of action homooligomerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes

Related original publications

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  1. Optogenetic Induction of Pyroptosis, Necroptosis, and Apoptosis in Mammalian Cell Lines. Bio Protoc, 2023
  2. Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape. Cell Syst, 2023
  3. RNA G-quadruplexes forming scaffolds for alpha-synuclein aggregation lead to progressive neurodegeneration. bioRxiv, 2023
  4. The Opto-inflammasome in zebrafish as a tool to study cell and tissue responses to speck formation and cell death. Elife, 2023
  5. Light-induced condensates show accumulation-prone and less dynamic properties in the nucleus compared to the cytoplasm. bioRxiv, 2023
  6. Optogenetic Activation of Ripk3 Reveals a Thresholding Mechanism in Intracellular and Intercellular Necroptosis. J Comput Soc Sci, 2023
  7. Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics. iScience, 2023
  8. DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling. Cell Rep, 2023
  9. Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles. Nat Commun, 2022
  10. Optogenetic control of GGGGCC repeat-containing RNA phase transition. Fundam res, 2022
  11. Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing. Nat Commun, 2022
  12. PPARγ phase separates with RXRα at PPREs to regulate target gene expression. Cell Discov, 2022
  13. Optogenetic activators of apoptosis, necroptosis, and pyroptosis. J Cell Biol, 2022
  14. Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae. J Vis Exp, 2022
  15. WNK kinases sense molecular crowding and rescue cell volume via phase separation. bioRxiv, 2022
  16. Optogenetic Manipulation of Cell Migration with High Spatiotemporal Resolution Using Lattice Lightsheet Microscopy. bioRxiv, 2022
  17. CeLINC, a fluorescence-based protein-protein interaction assay in Caenorhabditis elegans. Genetics, 2021
  18. Activation of endoplasmic reticulum stress via clustering of inner nuclear membrane proteins. bioRxiv, 2021
  19. Optogenetic activators of apoptosis, necroptosis and pyroptosis for probing cell death dynamics and bystander cell responses. bioRxiv, 2021
  20. Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy. Mol Cell, 2021
  21. Photon Upconversion Hydrogels for 3D Optogenetics. Adv Funct Mater, 2021
  22. Rac1 activation can generate untemplated, lamellar membrane ruffles. BMC Biol, 2021
  23. A modular tool to query and inducibly disrupt biomolecular condensates. Nat Commun, 2021
  24. Optogenetic manipulation of cellular communication using engineered myosin motors. Nat Cell Biol, 2021
  25. The proline-rich domain promotes Tau liquid-liquid phase separation in cells. J Cell Biol, 2020
  26. Nucleated transcriptional condensates amplify gene expression. Nat Cell Biol, 2020
  27. Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo. Neurobiol Dis, 2020
  28. Phosphofructokinase Relocalizes into Subcellular Compartments with Liquid-like Properties In Vivo. Biophys J, 2020
  29. m6A-binding YTHDF proteins promote stress granule formation. Nat Chem Biol, 2020
  30. Composition-dependent thermodynamics of intracellular phase separation. Nature, 2020
  31. Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering. Sci Adv, 2020
  32. Optogenetic manipulation of calcium signals in single T cells in vivo. Nat Commun, 2020
  33. Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons. Nat Commun, 2020
  34. Non-invasive optical control of endogenous Ca2+ channels in awake mice. Nat Commun, 2020
  35. Optogenetic inhibition of Delta reveals digital Notch signaling output during tissue differentiation. EMBO Rep, 2019
  36. Controlling the material properties and rRNA processing function of the nucleolus using light. Proc Natl Acad Sci USA, 2019
  37. Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments. EMBO J, 2019
  38. LADL: light-activated dynamic looping for endogenous gene expression control. Nat Methods, 2019
  39. Light-based control of metabolic flux through assembly of synthetic organelles. Nat Chem Biol, 2019
  40. NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop. Sci Signal, 2019
  41. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron, 2019
  42. Light-Induced Protein Clustering for Optogenetic Interference and Protein Interaction Analysis in Drosophila S2 Cells. Biomolecules, 2019
  43. Increasing spatial resolution of photoregulated GTPases through immobilized peripheral membrane proteins. Small GTPases, 2018
  44. Activation of EphB2 Forward Signaling Enhances Memory Consolidation. Cell Rep, 2018
  45. Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase. Neuron, 2018
  46. Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep, 2018
  47. Optogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase. Biol Open, 2017
  48. Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun, 2017
  49. Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2. Nat Commun, 2017
  50. Optogenetic control of the Dab1 signaling pathway. Sci Rep, 2017
  51. Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets. Cell, 2016
  52. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun, 2014