Photoreceptor CRY2olig
Binding partner /
Cofactor FAD
Source organism Arabidopsis thaliana
Mode of action homooligomerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes

Related original publications

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  1. Induction of the aggresome and insoluble tau aggregation using an optogenetic tool. bioRxiv, 2024
  2. Intracellular Tau Fragment Droplets Serve as Seeds for Tau Fibrils. bioRxiv, 2024
  3. A protein condensation network contextualises cell fate decisions. bioRxiv, 2024
  4. KIF2C-induced nuclear condensation concentrates PLK1 and phosphorylated BRCA2 at the kinetochore microtubules in mitosis. bioRxiv, 2024
  5. Engineering Material Properties of Transcription Factor Condensates to Control Gene Expression in Mammalian Cells and Mice. Small, 2024
  6. C9orf72 poly-PR condensation induces nuclear TDP-43 pathology and is inhibited by RNA in an optogenetic cell model. bioRxiv, 2024
  7. Optogenetic Regulation of EphA1 RTK Activation and Signaling. bioRxiv, 2024
  8. A platform to induce and mature biomolecular condensates using chemicals and light. Nat Chem Biol, 2024
  9. Optogenetic-mediated induction and monitoring of α-synuclein aggregation in cellular models of Parkinson's disease. STAR Protoc, 2023
  10. Prior Fc Receptor activation primes macrophages for increased sensitivity to IgG via long term and short term mechanisms. bioRxiv, 2023
  11. Light-induced trapping of endogenous proteins reveals spatiotemporal roles of microtubule and kinesin-1 in dendrite patterning of Drosophila sensory neurons. bioRxiv, 2023
  12. Optogenetic Induction of Pyroptosis, Necroptosis, and Apoptosis in Mammalian Cell Lines. Bio Protoc, 2023
  13. Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape. Cell Syst, 2023
  14. RNA G-quadruplexes forming scaffolds for alpha-synuclein aggregation lead to progressive neurodegeneration. bioRxiv, 2023
  15. Light-induced condensates show accumulation-prone and less dynamic properties in the nucleus compared to the cytoplasm. Spectrosc J, 2023
  16. The Opto-inflammasome in zebrafish as a tool to study cell and tissue responses to speck formation and cell death. Elife, 2023
  17. Optogenetic Activation of Ripk3 Reveals a Thresholding Mechanism in Intracellular and Intercellular Necroptosis. J Comput Soc Sci, 2023
  18. Structural basis of NINJ1-mediated plasma membrane rupture in cell death. Nature, 2023
  19. Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics. iScience, 2023
  20. DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling. Cell Rep, 2023
  21. Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles. Nat Commun, 2022
  22. WNK kinases sense molecular crowding and rescue cell volume via phase separation. Cell, 2022
  23. Optogenetic control of GGGGCC repeat-containing RNA phase transition. Fundam res, 2022
  24. Optogenetic manipulation of cell migration with high spatiotemporal resolution using lattice lightsheet microscopy. Commun Biol, 2022
  25. Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing. Nat Commun, 2022
  26. PPARγ phase separates with RXRα at PPREs to regulate target gene expression. Cell Discov, 2022
  27. Optogenetic activators of apoptosis, necroptosis, and pyroptosis. J Cell Biol, 2022
  28. Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae. J Vis Exp, 2022
  29. CeLINC, a fluorescence-based protein-protein interaction assay in Caenorhabditis elegans. Genetics, 2021
  30. Activation of endoplasmic reticulum stress via clustering of inner nuclear membrane proteins. bioRxiv, 2021
  31. Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy. Mol Cell, 2021
  32. Photon Upconversion Hydrogels for 3D Optogenetics. Adv Funct Mater, 2021
  33. Rac1 activation can generate untemplated, lamellar membrane ruffles. BMC Biol, 2021
  34. A modular tool to query and inducibly disrupt biomolecular condensates. Nat Commun, 2021
  35. Optogenetic manipulation of cellular communication using engineered myosin motors. Nat Cell Biol, 2021
  36. The proline-rich domain promotes Tau liquid-liquid phase separation in cells. J Cell Biol, 2020
  37. Nucleated transcriptional condensates amplify gene expression. Nat Cell Biol, 2020
  38. Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo. Neurobiol Dis, 2020
  39. Phosphofructokinase Relocalizes into Subcellular Compartments with Liquid-like Properties In Vivo. Biophys J, 2020
  40. m6A-binding YTHDF proteins promote stress granule formation. Nat Chem Biol, 2020
  41. Composition-dependent thermodynamics of intracellular phase separation. Nature, 2020
  42. Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering. Sci Adv, 2020
  43. Optogenetic manipulation of calcium signals in single T cells in vivo. Nat Commun, 2020
  44. Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons. Nat Commun, 2020
  45. Non-invasive optical control of endogenous Ca2+ channels in awake mice. Nat Commun, 2020
  46. Optogenetic inhibition of Delta reveals digital Notch signaling output during tissue differentiation. EMBO Rep, 2019
  47. Controlling the material properties and rRNA processing function of the nucleolus using light. Proc Natl Acad Sci USA, 2019
  48. Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments. EMBO J, 2019
  49. LADL: light-activated dynamic looping for endogenous gene expression control. Nat Methods, 2019
  50. Light-based control of metabolic flux through assembly of synthetic organelles. Nat Chem Biol, 2019
  51. NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop. Sci Signal, 2019
  52. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron, 2019
  53. Light-Induced Protein Clustering for Optogenetic Interference and Protein Interaction Analysis in Drosophila S2 Cells. Biomolecules, 2019
  54. Increasing spatial resolution of photoregulated GTPases through immobilized peripheral membrane proteins. Small GTPases, 2018
  55. Activation of EphB2 Forward Signaling Enhances Memory Consolidation. Cell Rep, 2018
  56. Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase. Neuron, 2018
  57. Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep, 2018
  58. Optogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase. Biol Open, 2017
  59. Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun, 2017
  60. Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2. Nat Commun, 2017
  61. Optogenetic control of the Dab1 signaling pathway. Sci Rep, 2017
  62. Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets. Cell, 2016
  63. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun, 2014
  64. Gene Delivery and Analysis of Optogenetic Induction of Lytic Cell Death. Curr Protoc, 2024