CRY2olig

Photoreceptor CRY2olig
Binding partner /
Cofactor FAD
Source organism Arabidopsis thaliana
Mode of action homooligomerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes

Related original publications

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  1. PPARγ phase separates with RXRα at PPREs to regulate target gene expression. Cell Discov, 2022
  2. Optogenetic activators of apoptosis, necroptosis, and pyroptosis. J Cell Biol, 2022
  3. WNK kinases sense molecular crowding and rescue cell volume via phase separation. bioRxiv, 2022
  4. Optogenetic Manipulation of Cell Migration with High Spatiotemporal Resolution Using Lattice Lightsheet Microscopy. bioRxiv, 2022
  5. CeLINC, a fluorescence-based protein-protein interaction assay in Caenorhabditis elegans. Genetics, 2021
  6. Activation of endoplasmic reticulum stress via clustering of inner nuclear membrane proteins. bioRxiv, 2021
  7. Optogenetic activators of apoptosis, necroptosis and pyroptosis for probing cell death dynamics and bystander cell responses. bioRxiv, 2021
  8. Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy. Mol Cell, 2021
  9. Photon Upconversion Hydrogels for 3D Optogenetics. Adv Funct Mater, 2021
  10. Rac1 activation can generate untemplated, lamellar membrane ruffles. BMC Biol, 2021
  11. A modular tool to query and inducibly disrupt biomolecular condensates. Nat Commun, 2021
  12. Optogenetic manipulation of cellular communication using engineered myosin motors. Nat Cell Biol, 2021
  13. The proline-rich domain promotes Tau liquid-liquid phase separation in cells. J Cell Biol, 2020
  14. Nucleated transcriptional condensates amplify gene expression. Nat Cell Biol, 2020
  15. Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo. Neurobiol Dis, 2020
  16. Phosphofructokinase Relocalizes into Subcellular Compartments with Liquid-like Properties In Vivo. Biophys J, 2020
  17. m6A-binding YTHDF proteins promote stress granule formation. Nat Chem Biol, 2020
  18. Composition-dependent thermodynamics of intracellular phase separation. Nature, 2020
  19. Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering. Sci Adv, 2020
  20. Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons. Nat Commun, 2020
  21. Non-invasive optical control of endogenous Ca2+ channels in awake mice. Nat Commun, 2020
  22. Optogenetic inhibition of Delta reveals digital Notch signaling output during tissue differentiation. EMBO Rep, 2019
  23. Controlling the material properties and rRNA processing function of the nucleolus using light. Proc Natl Acad Sci USA, 2019
  24. Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments. EMBO J, 2019
  25. LADL: light-activated dynamic looping for endogenous gene expression control. Nat Methods, 2019
  26. Light-based control of metabolic flux through assembly of synthetic organelles. Nat Chem Biol, 2019
  27. NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop. Sci Signal, 2019
  28. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron, 2019
  29. Light-Induced Protein Clustering for Optogenetic Interference and Protein Interaction Analysis in Drosophila S2 Cells. Biomolecules, 2019
  30. Increasing spatial resolution of photoregulated GTPases through immobilized peripheral membrane proteins. Small GTPases, 2018
  31. Activation of EphB2 Forward Signaling Enhances Memory Consolidation. Cell Rep, 2018
  32. Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase. Neuron, 2018
  33. Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep, 2018
  34. Optogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase. Biol Open, 2017
  35. Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun, 2017
  36. Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2. Nat Commun, 2017
  37. Optogenetic control of the Dab1 signaling pathway. Sci Rep, 2017
  38. Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets. Cell, 2016
  39. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun, 2014