CRY2/CRY2

Photoreceptor CRY2
Binding partner /
Cofactor FAD
Source organism Arabidopsis thaliana
Mode of action homooligomerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes

CRY2/CRY2-derived switches:

Related original publications

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  1. Optical activation of TrkA signaling. ACS Synth Biol, 2018
  2. Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli. Cell Syst, 2018
  3. Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase. Neuron, 2018
  4. Coupling optogenetics and light-sheet microscopy, a method to study Wnt signaling during embryogenesis. Sci Rep, 2017
  5. Optogenetic control of focal adhesion kinase signaling. Cell Signal, 2017
  6. Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun, 2017
  7. Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo. Elife, 2017
  8. Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2. Nat Commun, 2017
  9. Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts. Nat Commun, 2017
  10. Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions. Sci Rep, 2016
  11. Using HEK293T Expression System to Study Photoactive Plant Cryptochromes. Front Plant Sci, 2016
  12. Optogenetic activation of axon guidance receptors controls direction of neurite outgrowth. Sci Rep, 2016
  13. Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors. Sci Rep, 2016
  14. Optogenetic control of endogenous Ca(2+) channels in vivo. Nat Biotechnol, 2015
  15. The Dual Characteristics of Light-Induced Cryptochrome 2, Homo-oligomerization and Heterodimerization, for Optogenetic Manipulation in Mammalian Cells. ACS Synth Biol, 2015
  16. Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nat Commun, 2015
  17. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun, 2014
  18. Spatiotemporal control of fibroblast growth factor receptor signals by blue light. Chem Biol, 2014
  19. Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling. Nat Commun, 2014
  20. Optogenetic control of protein kinase activity in mammalian cells. ACS Synth Biol, 2013
  21. Formation of Arabidopsis Cryptochrome 2 photobodies in mammalian nuclei: application as an optogenetic DNA damage checkpoint switch. J Biol Chem, 2013
  22. Optogenetic protein clustering and signaling activation in mammalian cells. Nat Methods, 2013