CRY2/CRY2

Photoreceptor CRY2
Binding partner /
Cofactor FAD
Source organism Arabidopsis thaliana
Mode of action homooligomerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes
Crystal structure of CRY2. (PDB ID: 6K8I)

CRY2/CRY2-derived switches:

Related original publications

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  1. Multiple Sclerosis-Associated hnRNPA1 Mutations Alter hnRNPA1 Dynamics and Influence Stress Granule Formation. Int J Mol Sci, 2021
  2. TopBP1 assembles nuclear condensates to switch on ATR signaling. Mol Cell, 2021
  3. Liquid-liquid phase separation of light-inducible transcription factors increases transcription activation in mammalian cells and mice. Sci Adv, 2021
  4. Engineering Supramolecular Organizing Centers for Optogenetic Control of Innate Immune Responses. Adv Biol, 2020
  5. Use of Optogenetic Amyloid-β to Monitor Protein Aggregation in Drosophila melanogaster, Danio rerio and Caenorhabditis elegans. Bio Protoc, 2020
  6. Spatio-temporal Control of ERK Pulse Frequency Coordinates Fate Decisions during Mammary Acinar Morphogenesis. bioRxiv, 2020
  7. Spatiotemporal sensitivity of embryonic heart specification to FGFR signaling in Drosophila. bioRxiv, 2020
  8. β-Catenin signaling dynamics regulate cell fate in differentiating neural stem cells. Proc Natl Acad Sci U S A, 2020
  9. Clustering-based positive feedback between a kinase and its substrate enables effective T-cell receptor signaling. bioRxiv, 2020
  10. DMA-tudor interaction modules control the specificity of in vivo condensates. bioRxiv, 2020
  11. Novel culture system via wirelessly controllable optical stimulation of the FGF signaling pathway for human and pig pluripotency. Biomaterials, 2020
  12. Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival. bioRxiv, 2020
  13. Engineered Illumination Devices for Optogenetic Control of Cellular Signaling Dynamics. Cell Rep, 2020
  14. Optical Activation of TrkB Signaling. J Mol Biol, 2020
  15. Clustering of the ζ-Chain Can Initiate T Cell Receptor Signaling. Int J Mol Sci, 2020
  16. CLIC4 is a cytokinetic cleavage furrow protein that regulates cortical cytoskeleton stability during cell division. J Cell Sci, 2020
  17. Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement. Sci Adv, 2020
  18. Application of optogenetic Amyloid-β distinguishes between metabolic and physical damage in neurodegeneration. Elife, 2020
  19. An Optogenetic Method to Study Signal Transduction in Intestinal StemCell Homeostasis. J Mol Biol, 2020
  20. Robustness of epithelial sealing is an emerging property of local ERK feedbacks driven by cell elimination. bioRxiv, 2020
  21. Optogenetic manipulation of calcium signals in single T cells in vivo. Nat Commun, 2020
  22. Optogenetic modulation of TrkB signaling in the mouse brain. J Mol Biol, 2020
  23. Non-invasive optical control of endogenous Ca2+ channels in awake mice. Nat Commun, 2020
  24. Optical activation of TrkB receptors. bioRxiv, 2019
  25. Locally Activating TrkB Receptor Generates Actin Waves and Specifies Axonal Fate. Cell Chem Biol, 2019
  26. Optogenetic control of Wnt signaling for modeling early embryogenic patterning with human pluripotent stem cells. bioRxiv, 2019
  27. Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions. J Mol Biol, 2019
  28. Light-based control of metabolic flux through assembly of synthetic organelles. Nat Chem Biol, 2019
  29. Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology. Elife, 2019
  30. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron, 2019
  31. Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation. Mol Cell, 2019
  32. Intensiometric biosensors visualize the activity of multiple small GTPases in vivo. Nat Commun, 2019
  33. Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome. Cell, 2018
  34. Optogenetic dissection of Rac1 and Cdc42 gradient shaping. Nat Commun, 2018
  35. Optical activation of TrkA signaling. ACS Synth Biol, 2018
  36. Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli. Cell Syst, 2018
  37. Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase. Neuron, 2018
  38. Coupling optogenetics and light-sheet microscopy, a method to study Wnt signaling during embryogenesis. Sci Rep, 2017
  39. Optogenetic control of focal adhesion kinase signaling. Cell Signal, 2017
  40. Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun, 2017
  41. Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo. Elife, 2017
  42. Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2. Nat Commun, 2017
  43. Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts. Nat Commun, 2017
  44. Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions. Sci Rep, 2016
  45. Using HEK293T Expression System to Study Photoactive Plant Cryptochromes. Front Plant Sci, 2016
  46. Optogenetic activation of axon guidance receptors controls direction of neurite outgrowth. Sci Rep, 2016
  47. Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors. Sci Rep, 2016
  48. Optogenetic control of endogenous Ca(2+) channels in vivo. Nat Biotechnol, 2015
  49. The Dual Characteristics of Light-Induced Cryptochrome 2, Homo-oligomerization and Heterodimerization, for Optogenetic Manipulation in Mammalian Cells. ACS Synth Biol, 2015
  50. Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nat Commun, 2015
  51. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun, 2014
  52. Spatiotemporal control of fibroblast growth factor receptor signals by blue light. Chem Biol, 2014
  53. Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling. Nat Commun, 2014
  54. Optogenetic control of protein kinase activity in mammalian cells. ACS Synth Biol, 2013
  55. Formation of Arabidopsis Cryptochrome 2 photobodies in mammalian nuclei: application as an optogenetic DNA damage checkpoint switch. J Biol Chem, 2013
  56. Optogenetic protein clustering and signaling activation in mammalian cells. Nat Methods, 2013