An optogenetic approach to control and monitor inflammasome activation. bioRxiv, 2023
Optogenetic strategies for optimizing the performance of biosensors of membrane phospholipids in live cells. bioRxiv, 2023
Optogenetic control of Wnt signaling models cell-intrinsic embryogenic patterning using 2D human pluripotent stem cell culture. Development, 2023
Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons. Mol Brain, 2023
Sequence- and structure-specific RNA oligonucleotide binding attenuates heterogeneous nuclear ribonucleoprotein A1 dysfunction. Front Mol Biosci, 2023
mRNA condensation fluidizes the cytoplasm. bioRxiv, 2023
Optogenetic Activation of Ripk3 Reveals a Thresholding Mechanism in Intracellular and Intercellular Necroptosis. J Comput Soc Sci, 2023
Mechanosensitive stem cell fate choice is instructed by dynamic fluctuations in activation of Rho GTPases. Proc Natl Acad Sci U S A, 2023
Optogenetic manipulation identifies the roles of ERK and AKT dynamics in controlling mouse embryonic stem cell exit from pluripotency. Dev Cell, 2023
Light-stimulated insulin secretion from pancreatic islet-like organoids derived from human pluripotent stem cells. Mol Ther, 2023
Interaction between PI3K and the VDAC2 channel tethers Ras-PI3K-positive endosomes to mitochondria and promotes endosome maturation. Cell Rep, 2023
Enhancing Mitochondrial Functions by Optogenetic Clustering. bioRxiv, 2022
Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis. Dev Cell, 2022
CRY-BARs: Versatile light-gated molecular tools for the remodeling of membrane architectures. J Biol Chem, 2022
LITOS: a versatile LED illumination tool for optogenetic stimulation. Sci Rep, 2022
Visual detection of submicroscopic protein clusters with a phase-separation-based fluorescent reporter. bioRxiv, 2022
Integration of light and temperature sensing by liquid-liquid phase separation of phytochrome B. Mol Cell, 2022
Optical control of protein delivery and partitioning in the nucleolus. Nucleic Acids Res, 2022
The rate of information transmission through the MAPK/ERK signaling pathway stimulated in a pulsatile manner. bioRxiv, 2022
Oncogenic protein condensates modulate cell signal perception and drug tolerance. bioRxiv, 2022
Nucleation of the destruction complex on the centrosome accelerates degradation of β-catenin and regulates Wnt signal transmission. bioRxiv, 2022
Optogenetic control of Wnt signaling for modeling early embryogenic patterning with human pluripotent stem cells. bioRxiv, 2019
Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions. J Mol Biol, 2019
Light-based control of metabolic flux through assembly of synthetic organelles. Nat Chem Biol, 2019
Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology. Elife, 2019
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron, 2019
Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation. Mol Cell, 2019
Intensiometric biosensors visualize the activity of multiple small GTPases in vivo. Nat Commun, 2019
Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome. Cell, 2018
Optogenetic dissection of Rac1 and Cdc42 gradient shaping. Nat Commun, 2018
Optical activation of TrkA signaling. ACS Synth Biol, 2018
Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli. Cell Syst, 2018
Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase. Neuron, 2018
Coupling optogenetics and light-sheet microscopy, a method to study Wnt signaling during embryogenesis. Sci Rep, 2017
Optogenetic control of focal adhesion kinase signaling. Cell Signal, 2017
Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun, 2017
Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo. Elife, 2017
Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2. Nat Commun, 2017
Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts. Nat Commun, 2017
Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets. Cell, 2016
Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions. Sci Rep, 2016
Using HEK293T Expression System to Study Photoactive Plant Cryptochromes. Front Plant Sci, 2016
Optogenetic activation of axon guidance receptors controls direction of neurite outgrowth. Sci Rep, 2016
Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors. Sci Rep, 2016
Optogenetic control of endogenous Ca(2+) channels in vivo. Nat Biotechnol, 2015
The Dual Characteristics of Light-Induced Cryptochrome 2, Homo-oligomerization and Heterodimerization, for Optogenetic Manipulation in Mammalian Cells. ACS Synth Biol, 2015
Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nat Commun, 2015
An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun, 2014
Spatiotemporal control of fibroblast growth factor receptor signals by blue light. Chem Biol, 2014