CRY2/CRY2

Photoreceptor CRY2
Binding partner /
Cofactor FAD
Source organism Arabidopsis thaliana
Mode of action homooligomerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes

CRY2/CRY2-derived switches:

Related original publications

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  1. Optogenetic modulation of TrkB signaling in the mouse brain. J Mol Biol, 2020
  2. Locally Activating TrkB Receptor Generates Actin Waves and Specifies Axonal Fate. Cell Chem Biol, 2019
  3. CLIC4, a new component of the cytokinetic ring, regulates actin cytoskeleton dynamics during the anaphase-to-telophase transition. bioRxiv, 2019
  4. Engineered illumination devices for optogenetic control of cellular signaling dynamics. bioRxiv, 2019
  5. Optogenetic control of Wnt signaling for modeling early embryogenic patterning with human pluripotent stem cells. bioRxiv, 2019
  6. Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions. J Mol Biol, 2019
  7. Light-based control of metabolic flux through assembly of synthetic organelles. Nat Chem Biol, 2019
  8. Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology. Elife, 2019
  9. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron, 2019
  10. Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation. Mol Cell, 2019
  11. Intensiometric biosensors visualize the activity of multiple small GTPases in vivo. Nat Commun, 2019
  12. Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome. Cell, 2018
  13. Optogenetic dissection of Rac1 and Cdc42 gradient shaping. Nat Commun, 2018
  14. Optical activation of TrkA signaling. ACS Synth Biol, 2018
  15. Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli. Cell Syst, 2018
  16. Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase. Neuron, 2018
  17. Coupling optogenetics and light-sheet microscopy, a method to study Wnt signaling during embryogenesis. Sci Rep, 2017
  18. Optogenetic control of focal adhesion kinase signaling. Cell Signal, 2017
  19. Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun, 2017
  20. Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo. Elife, 2017
  21. Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2. Nat Commun, 2017
  22. Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts. Nat Commun, 2017
  23. Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions. Sci Rep, 2016
  24. Using HEK293T Expression System to Study Photoactive Plant Cryptochromes. Front Plant Sci, 2016
  25. Optogenetic activation of axon guidance receptors controls direction of neurite outgrowth. Sci Rep, 2016
  26. Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors. Sci Rep, 2016
  27. Optogenetic control of endogenous Ca(2+) channels in vivo. Nat Biotechnol, 2015
  28. The Dual Characteristics of Light-Induced Cryptochrome 2, Homo-oligomerization and Heterodimerization, for Optogenetic Manipulation in Mammalian Cells. ACS Synth Biol, 2015
  29. Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nat Commun, 2015
  30. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun, 2014
  31. Spatiotemporal control of fibroblast growth factor receptor signals by blue light. Chem Biol, 2014
  32. Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling. Nat Commun, 2014
  33. Optogenetic control of protein kinase activity in mammalian cells. ACS Synth Biol, 2013
  34. Formation of Arabidopsis Cryptochrome 2 photobodies in mammalian nuclei: application as an optogenetic DNA damage checkpoint switch. J Biol Chem, 2013
  35. Optogenetic protein clustering and signaling activation in mammalian cells. Nat Methods, 2013