CRY2/CRY2

Photoreceptor CRY2
Binding partner /
Cofactor FAD
Source organism Arabidopsis thaliana
Mode of action homooligomerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes

CRY2/CRY2-derived switches:

Related original publications

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  1. CLIC4, a new component of the cytokinetic ring, regulates actin cytoskeleton dynamics during the anaphase-to-telophase transition. bioRxiv, 2019
  2. Engineered illumination devices for optogenetic control of cellular signaling dynamics. bioRxiv, 2019
  3. Optogenetic control of Wnt signaling for modeling early embryogenic patterning with human pluripotent stem cells. bioRxiv, 2019
  4. Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions. J Mol Biol, 2019
  5. Light-based control of metabolic flux through assembly of synthetic organelles. Nat Chem Biol, 2019
  6. Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology. Elife, 2019
  7. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron, 2019
  8. Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation. Mol Cell, 2019
  9. Intensiometric biosensors visualize the activity of multiple small GTPases in vivo. Nat Commun, 2019
  10. Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome. Cell, 2018
  11. Optogenetic dissection of Rac1 and Cdc42 gradient shaping. Nat Commun, 2018
  12. Optical activation of TrkA signaling. ACS Synth Biol, 2018
  13. Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli. Cell Syst, 2018
  14. Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase. Neuron, 2018
  15. Coupling optogenetics and light-sheet microscopy, a method to study Wnt signaling during embryogenesis. Sci Rep, 2017
  16. Optogenetic control of focal adhesion kinase signaling. Cell Signal, 2017
  17. Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun, 2017
  18. Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo. Elife, 2017
  19. Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2. Nat Commun, 2017
  20. Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts. Nat Commun, 2017
  21. Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions. Sci Rep, 2016
  22. Using HEK293T Expression System to Study Photoactive Plant Cryptochromes. Front Plant Sci, 2016
  23. Optogenetic activation of axon guidance receptors controls direction of neurite outgrowth. Sci Rep, 2016
  24. Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors. Sci Rep, 2016
  25. Optogenetic control of endogenous Ca(2+) channels in vivo. Nat Biotechnol, 2015
  26. The Dual Characteristics of Light-Induced Cryptochrome 2, Homo-oligomerization and Heterodimerization, for Optogenetic Manipulation in Mammalian Cells. ACS Synth Biol, 2015
  27. Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nat Commun, 2015
  28. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun, 2014
  29. Spatiotemporal control of fibroblast growth factor receptor signals by blue light. Chem Biol, 2014
  30. Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling. Nat Commun, 2014
  31. Optogenetic control of protein kinase activity in mammalian cells. ACS Synth Biol, 2013
  32. Formation of Arabidopsis Cryptochrome 2 photobodies in mammalian nuclei: application as an optogenetic DNA damage checkpoint switch. J Biol Chem, 2013
  33. Optogenetic protein clustering and signaling activation in mammalian cells. Nat Methods, 2013