CRY2/CRY2

Photoreceptor CRY2
Binding partner /
Cofactor FAD
Source organism Arabidopsis thaliana
Mode of action homooligomerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes

CRY2/CRY2-derived switches:

Related original publications

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  1. Optical Activation of TrkB Signaling. J Mol Biol, 2020
  2. Clustering of the ζ-Chain Can Initiate T Cell Receptor Signaling. Int J Mol Sci, 2020
  3. CLIC4 is a cytokinetic cleavage furrow protein that regulates cortical cytoskeleton stability during cell division. J Cell Sci, 2020
  4. Application of optogenetic Amyloid-β distinguishes between metabolic and physical damage in neurodegeneration. Elife, 2020
  5. Application of optogenetic Amyloid-β distinguishes between metabolic and physical damages in neurodegeneration. Elife, 2020
  6. An Optogenetic Method to Study Signal Transduction in Intestinal StemCell Homeostasis. J Mol Biol, 2020
  7. Robustness of epithelial sealing is an emerging property of local ERK feedbacks driven by cell elimination. bioRxiv, 2020
  8. Optogenetic manipulation of calcium signals in single T cells in vivo. Nat Commun, 2020
  9. Optogenetic modulation of TrkB signaling in the mouse brain. J Mol Biol, 2020
  10. Non-invasive optical control of endogenous Ca2+ channels in awake mice. Nat Commun, 2020
  11. Optical activation of TrkB receptors. bioRxiv, 2019
  12. Locally Activating TrkB Receptor Generates Actin Waves and Specifies Axonal Fate. Cell Chem Biol, 2019
  13. Engineered illumination devices for optogenetic control of cellular signaling dynamics. bioRxiv, 2019
  14. Optogenetic control of Wnt signaling for modeling early embryogenic patterning with human pluripotent stem cells. bioRxiv, 2019
  15. Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions. J Mol Biol, 2019
  16. Light-based control of metabolic flux through assembly of synthetic organelles. Nat Chem Biol, 2019
  17. Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology. Elife, 2019
  18. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron, 2019
  19. Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation. Mol Cell, 2019
  20. Intensiometric biosensors visualize the activity of multiple small GTPases in vivo. Nat Commun, 2019
  21. Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome. Cell, 2018
  22. Optogenetic dissection of Rac1 and Cdc42 gradient shaping. Nat Commun, 2018
  23. Optical activation of TrkA signaling. ACS Synth Biol, 2018
  24. Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli. Cell Syst, 2018
  25. Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase. Neuron, 2018
  26. Coupling optogenetics and light-sheet microscopy, a method to study Wnt signaling during embryogenesis. Sci Rep, 2017
  27. Optogenetic control of focal adhesion kinase signaling. Cell Signal, 2017
  28. Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun, 2017
  29. Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo. Elife, 2017
  30. Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2. Nat Commun, 2017
  31. Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts. Nat Commun, 2017
  32. Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions. Sci Rep, 2016
  33. Using HEK293T Expression System to Study Photoactive Plant Cryptochromes. Front Plant Sci, 2016
  34. Optogenetic activation of axon guidance receptors controls direction of neurite outgrowth. Sci Rep, 2016
  35. Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors. Sci Rep, 2016
  36. Optogenetic control of endogenous Ca(2+) channels in vivo. Nat Biotechnol, 2015
  37. The Dual Characteristics of Light-Induced Cryptochrome 2, Homo-oligomerization and Heterodimerization, for Optogenetic Manipulation in Mammalian Cells. ACS Synth Biol, 2015
  38. Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nat Commun, 2015
  39. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun, 2014
  40. Spatiotemporal control of fibroblast growth factor receptor signals by blue light. Chem Biol, 2014
  41. Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling. Nat Commun, 2014
  42. Optogenetic control of protein kinase activity in mammalian cells. ACS Synth Biol, 2013
  43. Formation of Arabidopsis Cryptochrome 2 photobodies in mammalian nuclei: application as an optogenetic DNA damage checkpoint switch. J Biol Chem, 2013
  44. Optogenetic protein clustering and signaling activation in mammalian cells. Nat Methods, 2013