Photoreceptor CRY2clust
Binding partner /
Cofactor FAD
Source organism Arabidopsis thaliana
Mode of action homooligomerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes

Related original publications

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  1. Spatiotemporal Control of Inflammatory Lytic Cell Death Through Optogenetic Induction of RIPK3 Oligomerization. J Mol Biol, 2024
  2. Protein supersaturation powers innate immune signaling. bioRxiv, 2024
  3. Stress pathway outputs are encoded by pH-dependent phase separation of its components. bioRxiv, 2024
  4. Development of an optogenetics tool, Opto-RANK, for control of osteoclast differentiation using blue light. Sci Rep, 2024
  5. Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia. bioRxiv, 2023
  6. Optogenetic STING clustering system through nanobody-fused photoreceptor for innate immune regulation. Sens Actuators B Chem, 2023
  7. Visual quantification of prostaglandin E2 discharge from a single cell. Cell Struct Funct, 2023
  8. Optogenetic engineering of STING signaling allows remote immunomodulation to enhance cancer immunotherapy. Nat Commun, 2023
  9. Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape. Cell Syst, 2023
  10. Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation. Cell Stem Cell, 2023
  11. Light-activated macromolecular phase separation modulates transcription by reconfiguring chromatin interactions. Sci Adv, 2023
  12. Calcium transients trigger switch-like discharge of prostaglandin E2 (PGE2) in an ERK-dependent manner. bioRxiv, 2023
  13. A nucleation barrier spring-loads the CBM signalosome for binary activation. Elife, 2022
  14. Biophysical and biochemical properties of Deup1 self-assemblies: a potential driver for deuterosome formation during multiciliogenesis. Biol Open, 2021
  15. Non-invasive optical control of endogenous Ca2+ channels in awake mice. Nat Commun, 2020
  16. Flotillins promote T cell receptor sorting through a fast Rab5-Rab11 endocytic recycling axis. Nat Commun, 2019
  17. A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation. Nat Commun, 2018
  18. Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2. Nat Commun, 2017
  19. Gene Delivery and Analysis of Optogenetic Induction of Lytic Cell Death. Curr Protoc, 2024