Magnets

Photoreceptor pMag, nMag
Binding partner /
Cofactor FAD
Source organism Neurospora crassa
Mode of action heterodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds to hours (variants available)

Related original publications

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  1. Dynamic Multiplexed Control and Modeling of Optogenetic Systems Using the High-Throughput Optogenetic Platform, Lustro. ACS Synth Biol, 2024
  2. Optogenetic Control of Bacterial Cell-Cell Adhesion Dynamics: Unraveling the Influence on Biofilm Architecture and Functionality. Adv Sci (Weinh), 2024
  3. Programmable RNA base editing with photoactivatable CRISPR-Cas13. Nat Commun, 2024
  4. Development of an optogenetic gene expression system in Lactococcus lactis using a split photoactivatable T7 RNA polymerase. bioRxiv, 2024
  5. Photoactivation of LOV domains with chemiluminescence. Chem Sci, 2023
  6. Design and Engineering of Light-Induced Base Editors Facilitating Genome Editing with Enhanced Fidelity. Adv Sci (Weinh), 2023
  7. A programmable protease-based protein secretion platform for therapeutic applications. Nat Chem Biol, 2023
  8. Comprehensive Screening of a Light-Inducible Split Cre Recombinase with Domain Insertion Profiling. ACS Synth Biol, 2023
  9. Light-induced trapping of endogenous proteins reveals spatiotemporal roles of microtubule and kinesin-1 in dendrite patterning of Drosophila sensory neurons. bioRxiv, 2023
  10. Spatiotemporal, optogenetic control of gene expression in organoids. Nat Methods, 2023
  11. Photoactivatable base editors for spatiotemporally controlled genome editing in vivo. Biomaterials, 2023
  12. Diya – a universal light illumination platform for multiwell plate cultures. iScience, 2023
  13. High-Throughput Optogenetics Experiments in Yeast Using the Automated Platform Lustro. J Vis Exp, 2023
  14. Opto-RhoGEFs, an optimized optogenetic toolbox to reversibly control Rho GTPase activity on a global to subcellular scale, enabling precise control over vascular endothelial barrier strength. Elife, 2023
  15. Lustro: High-Throughput Optogenetic Experiments Enabled by Automation and a Yeast Optogenetic Toolkit. ACS Synth Biol, 2023
  16. A non-invasive photoactivatable split-Cre recombinase system for genome engineering in zebrafish. bioRxiv, 2023
  17. Synthetic Frizzled agonist and LRP antagonist for high-efficiency Wnt/β-catenin signaling manipulation in organoid cultures and in vivo. bioRxiv, 2023
  18. Detecting Photoactivatable Cre-mediated Gene Deletion Efficiency in Escherichia coli. Bio Protoc, 2023
  19. Generation of a photocontrollable recombinant bovine parainfluenza virus type 3. Microbiol Immunol, 2023
  20. Enhancing the performance of Magnets photosensors through directed evolution. bioRxiv, 2022
  21. Stable Transgenic Mouse Strain with Enhanced Photoactivatable Cre Recombinase for Spatiotemporal Genome Manipulation. Adv Sci (Weinh), 2022
  22. Blue Light Signaling Regulates Escherichia coli W1688 Biofilm Formation and l-Threonine Production. Microbiol Spectr, 2022
  23. Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback. Nat Commun, 2022
  24. Implementation of a Novel Optogenetic Tool in Mammalian Cells Based on a Split T7 RNA Polymerase. ACS Synth Biol, 2022
  25. Optogenetic Maxwell Demon to Exploit Intrinsic Noise and Control Cell Differentiation Despite Time Delays and Extrinsic Variability. bioRxiv, 2022
  26. Biochemical noise enables a single optogenetic input to control identical cells to track asymmetric and asynchronous reference signals. bioRxiv, 2022
  27. Spatio-temporal, optogenetic control of gene expression in organoids. bioRxiv, 2022
  28. Rapid and robust optogenetic control of gene expression in Drosophila. Dev Cell, 2021
  29. Exploiting Noise, Non-Linearity, and Feedback for Differential Control of Multiple Synthetic Cells with a Single Optogenetic Input. ACS Synth Biol, 2021
  30. Repetitive short-pulsed illumination efficiently activates photoactivatable-Cre as continuous illumination in embryonic stem cells and pre-implantation embryos of transgenic mouse. Genesis, 2021
  31. Optogenetic Tools for Manipulating Protein Subcellular Localization and Intracellular Signaling at Organelle Contact Sites. Curr Protoc, 2021
  32. A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch. Elife, 2021
  33. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A, 2020
  34. Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells. Elife, 2020
  35. Optogenetic regulation of embryo implantation in mice using photoactivatable CRISPR-Cas9. Proc Natl Acad Sci U S A, 2020
  36. Exploiting natural chemical photosensitivity of anhydrotetracycline and tetracycline for dynamic and setpoint chemo-optogenetic control. Nat Commun, 2020
  37. Bioluminescence-Triggered Photoswitchable Bacterial Adhesions Enable Higher Sensitivity and Dual-Readout Bacterial Biosensors for Mercury. ACS Sens, 2020
  38. Photoactivatable Cre recombinase 3.0 for in vivo mouse applications. Nat Commun, 2020
  39. Blue-Light-Switchable Bacterial Cell-Cell Adhesions Enable the Control of Multicellular Bacterial Communities. ACS Synth Biol, 2020
  40. Establishment of a tTA-dependent photoactivatable Cre recombinase knock-in mouse model for optogenetic genome engineering. Biochem Biophys Res Commun, 2020
  41. Light-Inducible Recombinases for Bacterial Optogenetics. ACS Synth Biol, 2020
  42. Engineered BRET-Based Biologic Light Sources Enable Spatiotemporal Control over Diverse Optogenetic Systems. ACS Synth Biol, 2019
  43. The importance of cell-cell interaction dynamics in bottom-up tissue engineering: Concepts of colloidal self-assembly in the fabrication of multicellular architectures. Nano Lett, 2019
  44. High-performance chemical- and light-inducible recombinases in mammalian cells and mice. Nat Commun, 2019
  45. Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins. Nat Methods, 2019
  46. An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics. ACS Synth Biol, 2019
  47. Near-infrared optogenetic genome engineering based on photon upconversion hydrogels. Angew Chem Int Ed Engl, 2019
  48. A split CRISPR-Cpf1 platform for inducible genome editing and gene activation. Nat Chem Biol, 2019
  49. Photocontrollable mononegaviruses. Proc Natl Acad Sci USA, 2019
  50. Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions. Nat Commun, 2019
  51. Reversible Social Self-Sorting of Colloidal Cell-Mimics with Blue Light Switchable Proteins. ACS Synth Biol, 2018
  52. Light-activated protein interaction with high spatial subcellular confinement. Proc Natl Acad Sci USA, 2018
  53. Optogenetic Control of Endoplasmic Reticulum-Mitochondria Tethering. ACS Synth Biol, 2017
  54. Dynamic Blue Light-Inducible T7 RNA Polymerases (Opto-T7RNAPs) for Precise Spatiotemporal Gene Expression Control. ACS Synth Biol, 2017
  55. CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation. Nat Methods, 2017
  56. Blue Light Switchable Bacterial Adhesion as a Key Step toward the Design of Biofilms. ACS Synth Biol, 2017
  57. Assembly Domain-Based Optogenetic System for the Efficient Control of Cellular Signaling. ACS Synth Biol, 2017
  58. Engineered Photoactivatable Genetic Switches Based on the Bacterium Phage T7 RNA Polymerase. ACS Synth Biol, 2016
  59. Optical manipulation of the alpha subunits of heterotrimeric G proteins using photoswitchable dimerization systems. Sci Rep, 2016
  60. A photoactivatable Cre-loxP recombination system for optogenetic genome engineering. Nat Chem Biol, 2016
  61. Photoactivatable CRISPR-Cas9 for optogenetic genome editing. Nat Biotechnol, 2015
  62. Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins. Nat Commun, 2015
  63. Optical Control of Genome Editing by Photoactivatable Cas9. Methods Mol Biol, 2021
  64. Optogenetic Activation of Intracellular Nanobodies. Methods Mol Biol, 2022
  65. Engineered Cas9 extracellular vesicles as a novel gene editing tool. J Extracell Vesicles, 2022
  66. Optical Control of Mononegavirus Gene Expression and Replication. Methods Mol Biol, 2024