Magnets

Photoreceptor pMag, nMag
Binding partner /
Cofactor FAD
Source organism Neurospora crassa
Mode of action heterodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds to hours (variants available)

Related original publications

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  1. Design and Implementation of a Blue-Light-Controlled Gene-Switch System. Molecules, 2026
  2. A non-invasive method for light-inducible knockout across all cell types in mouse subcutaneous adipose tissue. Adipocyte, 2026
  3. Engineering an Optogenetic pH-Modulator in Bacteria. Adv Sci (Weinh), 2026
  4. An extracellular, optogenetic antibody platform for stimulus-gated antigen recognition and modulation of cell behavior. Cell Chem Biol, 2026
  5. Optimized optogenetic anti-CRISPR for endogenous gene regulation in Drosophila. Nucleic Acids Res, 2026
  6. Light-inducible FLPase reconstitution enables temporal control of gene expression in Drosophila melanogaster. Cell Rep Methods, 2026
  7. Rationally designed light-inducible RNA-releasing protein for translational regulation and optogenetic control of gene therapies. Trends Biotechnol, 2026
  8. Enhancing the performance of Magnets photosensors. Nat Commun, 2026
  9. ShineGAL4 drivers for tissue and cell-type specific optogenetics in Drosophila. Development, 2026
  10. Single-cell characterization of bacterial optogenetic Cre recombinases. iScience, 2026
  11. Optogenetic control of biomolecular organization reveals distinct roles of phase separation in RTK signaling. Cell Chem Biol, 2025
  12. AlphaFold3-guided optimization of a photoactivatable endonuclease for top-down genome engineering. J Biol Chem, 2025
  13. De novo designed protein guiding targeted protein degradation. Nat Commun, 2025
  14. Single-cell characterization of bacterial optogenetic Cre recombinases. bioRxiv, 2025
  15. Digitizing the Blue Light-Activated T7 RNA Polymerase System with a tet-Controlled Riboregulator. ACS Synth Biol, 2025
  16. Multiplexing light-inducible recombinases to control cell fate, Boolean logic, and cell patterning in mammalian cells. Sci Adv, 2025
  17. Engineered depalmitoylases enable selective manipulation of protein localization and function. Nat Commun, 2025
  18. Application of the Magnet-Cre optogenetic system in the chicken model. Dev Biol, 2025
  19. A subcellular map of translational machinery composition and regulation at the single-molecule level. Science, 2025
  20. Complex optogenetic spatial patterning with split recombinase. bioRxiv, 2024
  21. In Vivo Optogenetics Based on Heavy Metal-Free Photon Upconversion Nanoparticles. Adv Mater, 2024
  22. Optogenetic control of early embryos labeling using photoactivatable Cre recombinase 3.0. FEBS Open Bio, 2024
  23. In vivo optogenetic manipulations of endogenous proteins reveal spatiotemporal roles of microtubule and kinesin in dendrite patterning. Sci Adv, 2024
  24. Dynamic Multiplexed Control and Modeling of Optogenetic Systems Using the High-Throughput Optogenetic Platform, Lustro. ACS Synth Biol, 2024
  25. Optogenetic Control of Bacterial Cell-Cell Adhesion Dynamics: Unraveling the Influence on Biofilm Architecture and Functionality. Adv Sci (Weinh), 2024
  26. Programmable RNA base editing with photoactivatable CRISPR-Cas13. Nat Commun, 2024
  27. Photoactivation of LOV domains with chemiluminescence. Chem Sci, 2023
  28. Design and Engineering of Light-Induced Base Editors Facilitating Genome Editing with Enhanced Fidelity. Adv Sci (Weinh), 2023
  29. A programmable protease-based protein secretion platform for therapeutic applications. Nat Chem Biol, 2023
  30. Comprehensive Screening of a Light-Inducible Split Cre Recombinase with Domain Insertion Profiling. ACS Synth Biol, 2023
  31. Spatiotemporal, optogenetic control of gene expression in organoids. Nat Methods, 2023
  32. Photoactivatable base editors for spatiotemporally controlled genome editing in vivo. Biomaterials, 2023
  33. Diya – a universal light illumination platform for multiwell plate cultures. iScience, 2023
  34. High-Throughput Optogenetics Experiments in Yeast Using the Automated Platform Lustro. J Vis Exp, 2023
  35. Opto-RhoGEFs, an optimized optogenetic toolbox to reversibly control Rho GTPase activity on a global to subcellular scale, enabling precise control over vascular endothelial barrier strength. Elife, 2023
  36. Lustro: High-Throughput Optogenetic Experiments Enabled by Automation and a Yeast Optogenetic Toolkit. ACS Synth Biol, 2023
  37. Detecting Photoactivatable Cre-mediated Gene Deletion Efficiency in Escherichia coli. Bio Protoc, 2023
  38. Generation of a photocontrollable recombinant bovine parainfluenza virus type 3. Microbiol Immunol, 2023
  39. Stable Transgenic Mouse Strain with Enhanced Photoactivatable Cre Recombinase for Spatiotemporal Genome Manipulation. Adv Sci (Weinh), 2022
  40. Blue Light Signaling Regulates Escherichia coli W1688 Biofilm Formation and l-Threonine Production. Microbiol Spectr, 2022
  41. Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback. Nat Commun, 2022
  42. Implementation of a Novel Optogenetic Tool in Mammalian Cells Based on a Split T7 RNA Polymerase. ACS Synth Biol, 2022
  43. Rapid and robust optogenetic control of gene expression in Drosophila. Dev Cell, 2021
  44. Exploiting Noise, Non-Linearity, and Feedback for Differential Control of Multiple Synthetic Cells with a Single Optogenetic Input. ACS Synth Biol, 2021
  45. Repetitive short-pulsed illumination efficiently activates photoactivatable-Cre as continuous illumination in embryonic stem cells and pre-implantation embryos of transgenic mouse. Genesis, 2021
  46. Optogenetic Tools for Manipulating Protein Subcellular Localization and Intracellular Signaling at Organelle Contact Sites. Curr Protoc, 2021
  47. A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch. Elife, 2021
  48. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A, 2020
  49. Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells. Elife, 2020
  50. Optogenetic regulation of embryo implantation in mice using photoactivatable CRISPR-Cas9. Proc Natl Acad Sci U S A, 2020
  51. Exploiting natural chemical photosensitivity of anhydrotetracycline and tetracycline for dynamic and setpoint chemo-optogenetic control. Nat Commun, 2020
  52. Bioluminescence-Triggered Photoswitchable Bacterial Adhesions Enable Higher Sensitivity and Dual-Readout Bacterial Biosensors for Mercury. ACS Sens, 2020
  53. Photoactivatable Cre recombinase 3.0 for in vivo mouse applications. Nat Commun, 2020
  54. Blue-Light-Switchable Bacterial Cell-Cell Adhesions Enable the Control of Multicellular Bacterial Communities. ACS Synth Biol, 2020
  55. Establishment of a tTA-dependent photoactivatable Cre recombinase knock-in mouse model for optogenetic genome engineering. Biochem Biophys Res Commun, 2020
  56. Light-Inducible Recombinases for Bacterial Optogenetics. ACS Synth Biol, 2020
  57. Engineered BRET-Based Biologic Light Sources Enable Spatiotemporal Control over Diverse Optogenetic Systems. ACS Synth Biol, 2019
  58. The importance of cell-cell interaction dynamics in bottom-up tissue engineering: Concepts of colloidal self-assembly in the fabrication of multicellular architectures. Nano Lett, 2019
  59. High-performance chemical- and light-inducible recombinases in mammalian cells and mice. Nat Commun, 2019
  60. Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins. Nat Methods, 2019
  61. An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics. ACS Synth Biol, 2019
  62. Near-infrared optogenetic genome engineering based on photon upconversion hydrogels. Angew Chem Int Ed Engl, 2019
  63. A split CRISPR-Cpf1 platform for inducible genome editing and gene activation. Nat Chem Biol, 2019
  64. Photocontrollable mononegaviruses. Proc Natl Acad Sci USA, 2019
  65. Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions. Nat Commun, 2019
  66. Reversible Social Self-Sorting of Colloidal Cell-Mimics with Blue Light Switchable Proteins. ACS Synth Biol, 2018
  67. Light-activated protein interaction with high spatial subcellular confinement. Proc Natl Acad Sci USA, 2018
  68. Optogenetic Control of Endoplasmic Reticulum-Mitochondria Tethering. ACS Synth Biol, 2017
  69. Dynamic Blue Light-Inducible T7 RNA Polymerases (Opto-T7RNAPs) for Precise Spatiotemporal Gene Expression Control. ACS Synth Biol, 2017
  70. CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation. Nat Methods, 2017
  71. Blue Light Switchable Bacterial Adhesion as a Key Step toward the Design of Biofilms. ACS Synth Biol, 2017
  72. Assembly Domain-Based Optogenetic System for the Efficient Control of Cellular Signaling. ACS Synth Biol, 2017
  73. Engineered Photoactivatable Genetic Switches Based on the Bacterium Phage T7 RNA Polymerase. ACS Synth Biol, 2016
  74. Optical manipulation of the alpha subunits of heterotrimeric G proteins using photoswitchable dimerization systems. Sci Rep, 2016
  75. A photoactivatable Cre-loxP recombination system for optogenetic genome engineering. Nat Chem Biol, 2016
  76. Photoactivatable CRISPR-Cas9 for optogenetic genome editing. Nat Biotechnol, 2015
  77. Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins. Nat Commun, 2015
  78. Optical Control of Genome Editing by Photoactivatable Cas9. Methods Mol Biol, 2021
  79. Optogenetic Activation of Intracellular Nanobodies. Methods Mol Biol, 2022
  80. Engineered Cas9 extracellular vesicles as a novel gene editing tool. J Extracell Vesicles, 2022
  81. Optical Control of Mononegavirus Gene Expression and Replication. Methods Mol Biol, 2024