Magnets

Photoreceptor pMag, nMag
Binding partner /
Cofactor FAD
Source organism Neurospora crassa
Mode of action heterodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds to hours (variants available)

Related original publications

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  1. A programmable protease-based protein secretion platform for therapeutic applications. Nat Chem Biol, 2023
  2. Comprehensive Screening of a Light-Inducible Split Cre Recombinase with Domain Insertion Profiling. ACS Synth Biol, 2023
  3. Light-induced trapping of endogenous proteins reveals spatiotemporal roles of microtubule and kinesin-1 in dendrite patterning of Drosophila sensory neurons. bioRxiv, 2023
  4. Spatiotemporal, optogenetic control of gene expression in organoids. Nat Methods, 2023
  5. Photoactivatable base editors for spatiotemporally controlled genome editing in vivo. Biomaterials, 2023
  6. Diya – a universal light illumination platform for multiwell plate cultures. iScience, 2023
  7. High-Throughput Optogenetics Experiments in Yeast Using the Automated Platform Lustro. J Vis Exp, 2023
  8. Opto-RhoGEFs, an optimized optogenetic toolbox to reversibly control Rho GTPase activity on a global to subcellular scale, enabling precise control over vascular endothelial barrier strength. Elife, 2023
  9. Lustro: High-Throughput Optogenetic Experiments Enabled by Automation and a Yeast Optogenetic Toolkit. ACS Synth Biol, 2023
  10. A non-invasive photoactivatable split-Cre recombinase system for genome engineering in zebrafish. bioRxiv, 2023
  11. Synthetic Frizzled agonist and LRP antagonist for high-efficiency Wnt/β-catenin signaling manipulation in organoid cultures and in vivo. bioRxiv, 2023
  12. Detecting Photoactivatable Cre-mediated Gene Deletion Efficiency in Escherichia coli. Bio Protoc, 2023
  13. Generation of a photocontrollable recombinant bovine parainfluenza virus type 3. Microbiol Immunol, 2023
  14. Enhancing the performance of Magnets photosensors through directed evolution. bioRxiv, 2022
  15. Stable Transgenic Mouse Strain with Enhanced Photoactivatable Cre Recombinase for Spatiotemporal Genome Manipulation. Adv Sci (Weinh), 2022
  16. Blue Light Signaling Regulates Escherichia coli W1688 Biofilm Formation and l-Threonine Production. Microbiol Spectr, 2022
  17. Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback. Nat Commun, 2022
  18. Implementation of a Novel Optogenetic Tool in Mammalian Cells Based on a Split T7 RNA Polymerase. ACS Synth Biol, 2022
  19. Optogenetic Maxwell Demon to Exploit Intrinsic Noise and Control Cell Differentiation Despite Time Delays and Extrinsic Variability. bioRxiv, 2022
  20. Biochemical noise enables a single optogenetic input to control identical cells to track asymmetric and asynchronous reference signals. bioRxiv, 2022
  21. Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback. bioRxiv, 2022
  22. Spatio-temporal, optogenetic control of gene expression in organoids. bioRxiv, 2022
  23. Rapid and robust optogenetic control of gene expression in Drosophila. Dev Cell, 2021
  24. Exploiting Noise, Non-Linearity, and Feedback for Differential Control of Multiple Synthetic Cells with a Single Optogenetic Input. ACS Synth Biol, 2021
  25. Repetitive short-pulsed illumination efficiently activates photoactivatable-Cre as continuous illumination in embryonic stem cells and pre-implantation embryos of transgenic mouse. Genesis, 2021
  26. Optogenetic Tools for Manipulating Protein Subcellular Localization and Intracellular Signaling at Organelle Contact Sites. Curr Protoc, 2021
  27. A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch. Elife, 2021
  28. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A, 2020
  29. Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells. Elife, 2020
  30. Optogenetic regulation of embryo implantation in mice using photoactivatable CRISPR-Cas9. Proc Natl Acad Sci U S A, 2020
  31. Exploiting natural chemical photosensitivity of anhydrotetracycline and tetracycline for dynamic and setpoint chemo-optogenetic control. Nat Commun, 2020
  32. Bioluminescence-Triggered Photoswitchable Bacterial Adhesions Enable Higher Sensitivity and Dual-Readout Bacterial Biosensors for Mercury. ACS Sens, 2020
  33. Photoactivatable Cre recombinase 3.0 for in vivo mouse applications. Nat Commun, 2020
  34. Blue-Light-Switchable Bacterial Cell-Cell Adhesions Enable the Control of Multicellular Bacterial Communities. ACS Synth Biol, 2020
  35. Establishment of a tTA-dependent photoactivatable Cre recombinase knock-in mouse model for optogenetic genome engineering. Biochem Biophys Res Commun, 2020
  36. Light-Inducible Recombinases for Bacterial Optogenetics. ACS Synth Biol, 2020
  37. Engineered BRET-Based Biologic Light Sources Enable Spatiotemporal Control over Diverse Optogenetic Systems. ACS Synth Biol, 2019
  38. The importance of cell-cell interaction dynamics in bottom-up tissue engineering: Concepts of colloidal self-assembly in the fabrication of multicellular architectures. Nano Lett, 2019
  39. High-performance chemical- and light-inducible recombinases in mammalian cells and mice. Nat Commun, 2019
  40. Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins. Nat Methods, 2019
  41. An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics. ACS Synth Biol, 2019
  42. Near-infrared optogenetic genome engineering based on photon upconversion hydrogels. Angew Chem Int Ed Engl, 2019
  43. A split CRISPR-Cpf1 platform for inducible genome editing and gene activation. Nat Chem Biol, 2019
  44. Photocontrollable mononegaviruses. Proc Natl Acad Sci USA, 2019
  45. Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions. Nat Commun, 2019
  46. Reversible Social Self-Sorting of Colloidal Cell-Mimics with Blue Light Switchable Proteins. ACS Synth Biol, 2018
  47. Light-activated protein interaction with high spatial subcellular confinement. Proc Natl Acad Sci USA, 2018
  48. Optogenetic Control of Endoplasmic Reticulum-Mitochondria Tethering. ACS Synth Biol, 2017
  49. Dynamic Blue Light-Inducible T7 RNA Polymerases (Opto-T7RNAPs) for Precise Spatiotemporal Gene Expression Control. ACS Synth Biol, 2017
  50. CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation. Nat Methods, 2017
  51. Blue Light Switchable Bacterial Adhesion as a Key Step toward the Design of Biofilms. ACS Synth Biol, 2017
  52. Assembly Domain-Based Optogenetic System for the Efficient Control of Cellular Signaling. ACS Synth Biol, 2017
  53. Engineered Photoactivatable Genetic Switches Based on the Bacterium Phage T7 RNA Polymerase. ACS Synth Biol, 2016
  54. Optical manipulation of the alpha subunits of heterotrimeric G proteins using photoswitchable dimerization systems. Sci Rep, 2016
  55. A photoactivatable Cre-loxP recombination system for optogenetic genome engineering. Nat Chem Biol, 2016
  56. Photoactivatable CRISPR-Cas9 for optogenetic genome editing. Nat Biotechnol, 2015
  57. Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins. Nat Commun, 2015
  58. Optical Control of Genome Editing by Photoactivatable Cas9. Methods Mol Biol, 2021
  59. Optogenetic Activation of Intracellular Nanobodies. Methods Mol Biol, 2022
  60. Engineered Cas9 extracellular vesicles as a novel gene editing tool. J Extracell Vesicles, 2022