VVD

Photoreceptor VVD
Binding partner /
Cofactor FMN or FAD
Source organism Neurospora crassa
Mode of action homodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time hours
Crystal structure of the VVD homodimer. (PDB ID: 3RH8)

VVD-derived switches:

Related original publications

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  1. Noise-reducing optogenetic negative-feedback gene circuits in human cells. Nucleic Acids Res, 2019
  2. Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions. J Mol Biol, 2019
  3. Independent Blue and Red Light Triggered Narcissistic Self-Sorting Self-Assembly of Colloidal Particles. Small, 2019
  4. Direct observation and analysis of the dynamics of the photoresponsive transcription factor GAL4. Angew Chem Int Ed Engl, 2019
  5. A Single-Component Optogenetic System Allows Stringent Switch of Gene Expression in Yeast Cells. ACS Synth Biol, 2018
  6. Fungal Light-Oxygen-Voltage Domains for Optogenetic Control of Gene Expression and Flocculation in Yeast. MBio, 2018
  7. Near-infrared light-controlled systems for gene transcription regulation, protein targeting and spectral multiplexing. Nat Protoc, 2018
  8. An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions. J Vis Exp, 2018
  9. Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information. Genes Dev, 2017
  10. Near-infrared optogenetic pair for protein regulation and spectral multiplexing. Nat Chem Biol, 2017
  11. Engineered Photoactivatable Genetic Switches Based on the Bacterium Phage T7 RNA Polymerase. ACS Synth Biol, 2016
  12. A light-switchable bidirectional expression system in filamentous fungus Trichoderma reesei. J Biotechnol, 2016
  13. Light-induced Notch activity controls neurogenic and gliogenic potential of neural progenitors. Biochem Biophys Res Commun, 2016
  14. An extraordinary stringent and sensitive light-switchable gene expression system for bacterial cells. Cell Res, 2016
  15. A bacterial phytochrome-based optogenetic system controllable with near-infrared light. Nat Methods, 2016
  16. Rewiring Multidomain Protein Switches: Transforming a Fluorescent Zn(2+) Sensor into a Light-Responsive Zn(2+) Binding Protein. ACS Synth Biol, 2016
  17. Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light. Nucleic Acids Res, 2015
  18. A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes. Biochem Biophys Res Commun, 2015
  19. Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins. Nat Commun, 2015
  20. Orthogonal optogenetic triple-gene control in Mammalian cells. ACS Synth Biol, 2014
  21. Spatio-temporally precise activation of engineered receptor tyrosine kinases by light. EMBO J, 2014
  22. Light-mediated control of gene expression in filamentous fungus Trichoderma reesei. J Microbiol Methods, 2014
  23. Genetically engineered photoinducible homodimerization system with improved dimer-forming efficiency. ACS Chem Biol, 2014
  24. Fine tuning the LightOn light-switchable transgene expression system. Biochem Biophys Res Commun, 2013
  25. Multi-chromatic control of mammalian gene expression and signaling. Nucleic Acids Res, 2013
  26. Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods, 2012