VVD

Photoreceptor VVD
Binding partner /
Cofactor FMN or FAD
Source organism Neurospora crassa
Mode of action homodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time hours
Crystal structure of the VVD homodimer. (PDB ID: 3RH8)

VVD-derived switches:

Related original publications

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  1. Dimerization activates the Inversin complex in C. elegans. bioRxiv, 2024
  2. Spatiotemporally controlled Pseudomonas exotoxin transgene system combined with multifunctional nanoparticles for breast cancer antimetastatic therapy. J Control Release, 2024
  3. Photoactivation of LOV domains with chemiluminescence. Chem Sci, 2023
  4. Spatiotemporal control of RNA metabolism and CRISPR-Cas functions using engineered photoswitchable RNA-binding proteins. Nat Protoc, 2023
  5. Full-field exposure of larval zebrafish to narrow waveband LED light sources at defined power and energy for optogenetic applications. J Neurosci Methods, 2023
  6. Diya – a universal light illumination platform for multiwell plate cultures. iScience, 2023
  7. A biological camera that captures and stores images directly into DNA. Nat Commun, 2023
  8. OPTO-BLUE: An Integrated Bidirectional Optogenetic Lentiviral Platform for Controlled Light-Induced Gene Expression. Int J Mol Sci, 2023
  9. Controlling protein stability with SULI, a highly sensitive tag for stabilization upon light induction. Nat Commun, 2023
  10. A Single-Component Optogenetic Gal4-UAS System Allows Stringent Control of Gene Expression in Zebrafish and Drosophila. ACS Synth Biol, 2023
  11. An optogenetic toolkit for light-inducible antibiotic resistance. Nat Commun, 2023
  12. Spatiotemporally controllable diphtherin transgene system and neoantigen immunotherapy. J Control Release, 2023
  13. Coupling Cell Communication and Optogenetics: Implementation of a Light-Inducible Intercellular System in Yeast. ACS Synth Biol, 2022
  14. Enhancement of Vivid-based Photo-Activatable Gal4 Transcription Factor in Mammalian Cells. Cell Struct Funct, 2022
  15. Expanding the molecular versatility of an optogenetic switch in yeast. Front Bioeng Biotechnol, 2022
  16. Opto-katanin, an optogenetic tool for localized, microtubule disassembly. Curr Biol, 2022
  17. Implementation of a Novel Optogenetic Tool in Mammalian Cells Based on a Split T7 RNA Polymerase. ACS Synth Biol, 2022
  18. Light-switchable diphtherin transgene system combined with losartan for triple negtative breast cancer therapy based on nano drug delivery system. Int J Pharm, 2022
  19. Bifunctional optogenetic switch for improving shikimic acid production in E. coli. Biotechnol Biofuels, 2022
  20. Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins. Nat Biotechnol, 2022
  21. Modular and Molecular Optimization of a LOV (Light-Oxygen-Voltage)-Based Optogenetic Switch in Yeast. Int J Mol Sci, 2021
  22. Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells. J Vis Exp, 2021
  23. A Light-Oxygen-Voltage Receptor Integrates Light and Temperature. J Mol Biol, 2021
  24. Engineering AraC to make it responsive to light instead of arabinose. Nat Chem Biol, 2021
  25. Optimization of the Light-On system in a lentiviral platform to a light-controlled expression of genes in neurons. Electron J Biotechnol, 2021
  26. Light-induced local gene expression in primary chick cell culture system. Dev Growth Differ, 2021
  27. A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nat Commun, 2021
  28. Photobiologically Directed Assembly of Gold Nanoparticles. Adv Biol, 2020
  29. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A, 2020
  30. Light-Regulated allosteric switch enables temporal and subcellular control of enzyme activity. Elife, 2020
  31. Spatiotemporal regulation of ubiquitin-mediated protein degradation via upconversion optogenetic nanosystem. Nano Res, 2020
  32. Photoactivatable oncolytic adenovirus for optogenetic cancer therapy. Cell Death Dis, 2020
  33. Orthogonal Blue and Red Light Controlled Cell-Cell Adhesions Enable Sorting-out in Multicellular Structures. ACS Synth Biol, 2020
  34. Targeted cell ablation in zebrafish using optogenetic transcriptional control. Development, 2020
  35. A Light-Inducible Strain for Genome-Wide Histone Turnover Profiling in Neurospora crassa. Genetics, 2020
  36. A combination of LightOn gene expression system and tumor microenvironment-responsive nanoparticle delivery system for targeted breast cancer therapy. Acta Pharm Sin B, 2020
  37. An optimized toolbox for the optogenetic control of intracellular transport. J Cell Biol, 2020
  38. RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations. Nat Methods, 2020
  39. Light-Inducible Recombinases for Bacterial Optogenetics. ACS Synth Biol, 2020
  40. Coupling delay controls synchronized oscillation in the segmentation clock. Nature, 2020
  41. Noise-reducing optogenetic negative-feedback gene circuits in human cells. Nucleic Acids Res, 2019
  42. Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions. J Mol Biol, 2019
  43. Independent Blue and Red Light Triggered Narcissistic Self-Sorting Self-Assembly of Colloidal Particles. Small, 2019
  44. Direct observation and analysis of the dynamics of the photoresponsive transcription factor GAL4. Angew Chem Int Ed Engl, 2019
  45. A Single-Component Optogenetic System Allows Stringent Switch of Gene Expression in Yeast Cells. ACS Synth Biol, 2018
  46. Fungal Light-Oxygen-Voltage Domains for Optogenetic Control of Gene Expression and Flocculation in Yeast. MBio, 2018
  47. Near-infrared light-controlled systems for gene transcription regulation, protein targeting and spectral multiplexing. Nat Protoc, 2018
  48. An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions. J Vis Exp, 2018
  49. Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information. Genes Dev, 2017
  50. Near-infrared optogenetic pair for protein regulation and spectral multiplexing. Nat Chem Biol, 2017
  51. Engineered Photoactivatable Genetic Switches Based on the Bacterium Phage T7 RNA Polymerase. ACS Synth Biol, 2016
  52. A light-switchable bidirectional expression system in filamentous fungus Trichoderma reesei. J Biotechnol, 2016
  53. Light-induced Notch activity controls neurogenic and gliogenic potential of neural progenitors. Biochem Biophys Res Commun, 2016
  54. An extraordinary stringent and sensitive light-switchable gene expression system for bacterial cells. Cell Res, 2016
  55. A bacterial phytochrome-based optogenetic system controllable with near-infrared light. Nat Methods, 2016
  56. Rewiring Multidomain Protein Switches: Transforming a Fluorescent Zn(2+) Sensor into a Light-Responsive Zn(2+) Binding Protein. ACS Synth Biol, 2016
  57. Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light. Nucleic Acids Res, 2015
  58. A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes. Biochem Biophys Res Commun, 2015
  59. Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins. Nat Commun, 2015
  60. Orthogonal optogenetic triple-gene control in Mammalian cells. ACS Synth Biol, 2014
  61. Spatio-temporally precise activation of engineered receptor tyrosine kinases by light. EMBO J, 2014
  62. Light-mediated control of gene expression in filamentous fungus Trichoderma reesei. J Microbiol Methods, 2014
  63. Genetically engineered photoinducible homodimerization system with improved dimer-forming efficiency. ACS Chem Biol, 2014
  64. Fine tuning the LightOn light-switchable transgene expression system. Biochem Biophys Res Commun, 2013
  65. Multi-chromatic control of mammalian gene expression and signaling. Nucleic Acids Res, 2013
  66. Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods, 2012
  67. Engineered Cas9 extracellular vesicles as a novel gene editing tool. J Extracell Vesicles, 2022