VVD

Photoreceptor VVD
Binding partner /
Cofactor FMN or FAD
Source organism Neurospora crassa
Mode of action homodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time hours
Crystal structure of the VVD homodimer. (PDB ID: 3RH8)

VVD-derived switches:

Related original publications

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  1. Implementation of a Novel Optogenetic Tool in Mammalian Cells Based on a Split T7 RNA Polymerase. ACS Synth Biol, 2022
  2. Light-switchable diphtherin transgene system combined with losartan for triple negtative breast cancer therapy based on nano drug delivery system. Int J Pharm, 2022
  3. Bifunctional optogenetic switch for improving shikimic acid production in E. coli. Biotechnol Biofuels, 2022
  4. Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins. Nat Biotechnol, 2022
  5. Opto-Katanin: An Optogenetic Tool for Localized Microtubule Disassembly. bioRxiv, 2021
  6. Modular and Molecular Optimization of a LOV (Light-Oxygen-Voltage)-Based Optogenetic Switch in Yeast. Int J Mol Sci, 2021
  7. Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells. J Vis Exp, 2021
  8. A Light-Oxygen-Voltage Receptor Integrates Light and Temperature. J Mol Biol, 2021
  9. Engineering AraC to make it responsive to light instead of arabinose. Nat Chem Biol, 2021
  10. Light-induced local gene expression in primary chick cell culture system. Dev Growth Differ, 2021
  11. A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nat Commun, 2021
  12. Photobiologically Directed Assembly of Gold Nanoparticles. Adv Biol, 2020
  13. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A, 2020
  14. Light-Regulated allosteric switch enables temporal and subcellular control of enzyme activity. Elife, 2020
  15. Spatiotemporal regulation of ubiquitin-mediated protein degradation via upconversion optogenetic nanosystem. Nano Res, 2020
  16. Photoactivatable oncolytic adenovirus for optogenetic cancer therapy. Cell Death Dis, 2020
  17. Orthogonal Blue and Red Light Controlled Cell-Cell Adhesions Enable Sorting-out in Multicellular Structures. ACS Synth Biol, 2020
  18. Targeted cell ablation in zebrafish using optogenetic transcriptional control. Development, 2020
  19. A Light-Inducible Strain for Genome-Wide Histone Turnover Profiling in Neurospora crassa. Genetics, 2020
  20. A combination of LightOn gene expression system and tumor microenvironment-responsive nanoparticle delivery system for targeted breast cancer therapy. Acta Pharm Sin B, 2020
  21. An optimized toolbox for the optogenetic control of intracellular transport. J Cell Biol, 2020
  22. RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations. Nat Methods, 2020
  23. Light-Inducible Recombinases for Bacterial Optogenetics. ACS Synth Biol, 2020
  24. Coupling delay controls synchronized oscillation in the segmentation clock. Nature, 2020
  25. Noise-reducing optogenetic negative-feedback gene circuits in human cells. Nucleic Acids Res, 2019
  26. Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions. J Mol Biol, 2019
  27. Independent Blue and Red Light Triggered Narcissistic Self-Sorting Self-Assembly of Colloidal Particles. Small, 2019
  28. Direct observation and analysis of the dynamics of the photoresponsive transcription factor GAL4. Angew Chem Int Ed Engl, 2019
  29. A Single-Component Optogenetic System Allows Stringent Switch of Gene Expression in Yeast Cells. ACS Synth Biol, 2018
  30. Fungal Light-Oxygen-Voltage Domains for Optogenetic Control of Gene Expression and Flocculation in Yeast. MBio, 2018
  31. Near-infrared light-controlled systems for gene transcription regulation, protein targeting and spectral multiplexing. Nat Protoc, 2018
  32. An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions. J Vis Exp, 2018
  33. Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information. Genes Dev, 2017
  34. Near-infrared optogenetic pair for protein regulation and spectral multiplexing. Nat Chem Biol, 2017
  35. Engineered Photoactivatable Genetic Switches Based on the Bacterium Phage T7 RNA Polymerase. ACS Synth Biol, 2016
  36. A light-switchable bidirectional expression system in filamentous fungus Trichoderma reesei. J Biotechnol, 2016
  37. Light-induced Notch activity controls neurogenic and gliogenic potential of neural progenitors. Biochem Biophys Res Commun, 2016
  38. An extraordinary stringent and sensitive light-switchable gene expression system for bacterial cells. Cell Res, 2016
  39. A bacterial phytochrome-based optogenetic system controllable with near-infrared light. Nat Methods, 2016
  40. Rewiring Multidomain Protein Switches: Transforming a Fluorescent Zn(2+) Sensor into a Light-Responsive Zn(2+) Binding Protein. ACS Synth Biol, 2016
  41. Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light. Nucleic Acids Res, 2015
  42. A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes. Biochem Biophys Res Commun, 2015
  43. Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins. Nat Commun, 2015
  44. Orthogonal optogenetic triple-gene control in Mammalian cells. ACS Synth Biol, 2014
  45. Spatio-temporally precise activation of engineered receptor tyrosine kinases by light. EMBO J, 2014
  46. Light-mediated control of gene expression in filamentous fungus Trichoderma reesei. J Microbiol Methods, 2014
  47. Genetically engineered photoinducible homodimerization system with improved dimer-forming efficiency. ACS Chem Biol, 2014
  48. Fine tuning the LightOn light-switchable transgene expression system. Biochem Biophys Res Commun, 2013
  49. Multi-chromatic control of mammalian gene expression and signaling. Nucleic Acids Res, 2013
  50. Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods, 2012
  51. Engineered Cas9 extracellular vesicles as a novel gene editing tool. J Extracell Vesicles, 2022