VVD

Photoreceptor VVD
Binding partner /
Cofactor FMN or FAD
Source organism Neurospora crassa
Mode of action homodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time hours
Crystal structure of the VVD homodimer. (PDB ID: 3RH8)

VVD-derived switches:

Related original publications

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  1. Light-Regulated allosteric switch enables temporal and subcellular control of enzyme activity. Elife, 2020
  2. Spatiotemporal regulation of ubiquitin-mediated protein degradation via upconversion optogenetic nanosystem. Nano Res, 2020
  3. Photoactivatable oncolytic adenovirus for optogenetic cancer therapy. Cell Death Dis, 2020
  4. Orthogonal Blue and Red Light Controlled Cell-Cell Adhesions Enable Sorting-out in Multicellular Structures. ACS Synth Biol, 2020
  5. A Light-Inducible Strain for Genome-Wide Histone Turnover Profiling in Neurospora crassa. Genetics, 2020
  6. A combination of LightOn gene expression system and tumor microenvironment-responsive nanoparticle delivery system for targeted breast cancer therapy. Acta Pharm Sin B, 2020
  7. An optimized toolbox for the optogenetic control of intracellular transport. J Cell Biol, 2020
  8. RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations. Nat Methods, 2020
  9. Light-Inducible Recombinases for Bacterial Optogenetics. ACS Synth Biol, 2020
  10. Coupling delay controls synchronized oscillation in the segmentation clock. Nature, 2020
  11. Targeted cell ablation in zebrafish using optogenetic transcriptional control. bioRxiv, 2019
  12. Noise-reducing optogenetic negative-feedback gene circuits in human cells. Nucleic Acids Res, 2019
  13. Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions. J Mol Biol, 2019
  14. Independent Blue and Red Light Triggered Narcissistic Self-Sorting Self-Assembly of Colloidal Particles. Small, 2019
  15. Direct observation and analysis of the dynamics of the photoresponsive transcription factor GAL4. Angew Chem Int Ed Engl, 2019
  16. A Single-Component Optogenetic System Allows Stringent Switch of Gene Expression in Yeast Cells. ACS Synth Biol, 2018
  17. Fungal Light-Oxygen-Voltage Domains for Optogenetic Control of Gene Expression and Flocculation in Yeast. MBio, 2018
  18. Near-infrared light-controlled systems for gene transcription regulation, protein targeting and spectral multiplexing. Nat Protoc, 2018
  19. An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions. J Vis Exp, 2018
  20. Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information. Genes Dev, 2017
  21. Near-infrared optogenetic pair for protein regulation and spectral multiplexing. Nat Chem Biol, 2017
  22. Engineered Photoactivatable Genetic Switches Based on the Bacterium Phage T7 RNA Polymerase. ACS Synth Biol, 2016
  23. A light-switchable bidirectional expression system in filamentous fungus Trichoderma reesei. J Biotechnol, 2016
  24. Light-induced Notch activity controls neurogenic and gliogenic potential of neural progenitors. Biochem Biophys Res Commun, 2016
  25. An extraordinary stringent and sensitive light-switchable gene expression system for bacterial cells. Cell Res, 2016
  26. A bacterial phytochrome-based optogenetic system controllable with near-infrared light. Nat Methods, 2016
  27. Rewiring Multidomain Protein Switches: Transforming a Fluorescent Zn(2+) Sensor into a Light-Responsive Zn(2+) Binding Protein. ACS Synth Biol, 2016
  28. Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light. Nucleic Acids Res, 2015
  29. A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes. Biochem Biophys Res Commun, 2015
  30. Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins. Nat Commun, 2015
  31. Orthogonal optogenetic triple-gene control in Mammalian cells. ACS Synth Biol, 2014
  32. Spatio-temporally precise activation of engineered receptor tyrosine kinases by light. EMBO J, 2014
  33. Light-mediated control of gene expression in filamentous fungus Trichoderma reesei. J Microbiol Methods, 2014
  34. Genetically engineered photoinducible homodimerization system with improved dimer-forming efficiency. ACS Chem Biol, 2014
  35. Fine tuning the LightOn light-switchable transgene expression system. Biochem Biophys Res Commun, 2013
  36. Multi-chromatic control of mammalian gene expression and signaling. Nucleic Acids Res, 2013
  37. Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods, 2012