VVD

Photoreceptor VVD
Binding partner /
Cofactor FMN or FAD
Source organism Neurospora crassa
Mode of action homodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time hours
Crystal structure of the VVD homodimer. (PDB ID: 3RH8)

VVD-derived switches:

Related original publications

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  1. A Single-Component Optogenetic System Allows Stringent Switch of Gene Expression in Yeast Cells. ACS Synth Biol, 2018
  2. Fungal Light-Oxygen-Voltage Domains for Optogenetic Control of Gene Expression and Flocculation in Yeast. MBio, 2018
  3. Near-infrared light-controlled systems for gene transcription regulation, protein targeting and spectral multiplexing. Nat Protoc, 2018
  4. An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions. J Vis Exp, 2018
  5. Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information. Genes Dev, 2017
  6. Near-infrared optogenetic pair for protein regulation and spectral multiplexing. Nat Chem Biol, 2017
  7. Engineered Photoactivatable Genetic Switches Based on the Bacterium Phage T7 RNA Polymerase. ACS Synth Biol, 2016
  8. A light-switchable bidirectional expression system in filamentous fungus Trichoderma reesei. J Biotechnol, 2016
  9. Light-induced Notch activity controls neurogenic and gliogenic potential of neural progenitors. Biochem Biophys Res Commun, 2016
  10. An extraordinary stringent and sensitive light-switchable gene expression system for bacterial cells. Cell Res, 2016
  11. A bacterial phytochrome-based optogenetic system controllable with near-infrared light. Nat Methods, 2016
  12. Rewiring Multidomain Protein Switches: Transforming a Fluorescent Zn(2+) Sensor into a Light-Responsive Zn(2+) Binding Protein. ACS Synth Biol, 2016
  13. Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light. Nucleic Acids Res, 2015
  14. A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes. Biochem Biophys Res Commun, 2015
  15. Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins. Nat Commun, 2015
  16. Orthogonal optogenetic triple-gene control in Mammalian cells. ACS Synth Biol, 2014
  17. Spatio-temporally precise activation of engineered receptor tyrosine kinases by light. EMBO J, 2014
  18. Light-mediated control of gene expression in filamentous fungus Trichoderma reesei. J Microbiol Methods, 2014
  19. Genetically engineered photoinducible homodimerization system with improved dimer-forming efficiency. ACS Chem Biol, 2014
  20. Fine tuning the LightOn light-switchable transgene expression system. Biochem Biophys Res Commun, 2013
  21. Multi-chromatic control of mammalian gene expression and signaling. Nucleic Acids Res, 2013
  22. Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods, 2012