VVD

Photoreceptor VVD
Binding partner /
Cofactor FMN or FAD
Source organism Neurospora crassa
Mode of action homodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time hours
Crystal structure of the VVD homodimer. (PDB ID: 3RH8)

VVD-derived switches:

Related original publications

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  1. Controlling protein stability with SULI, a highly sensitive tag for stabilization upon light induction. Nat Commun, 2023
  2. A Single-Component Optogenetic Gal4-UAS System Allows Stringent Control of Gene Expression in Zebrafish and Drosophila. ACS Synth Biol, 2023
  3. An optogenetic toolkit for light-inducible antibiotic resistance. Nat Commun, 2023
  4. Spatiotemporally controllable diphtherin transgene system and neoantigen immunotherapy. J Control Release, 2023
  5. Coupling Cell Communication and Optogenetics: Implementation of a Light-Inducible Intercellular System in Yeast. ACS Synth Biol, 2022
  6. Enhancement of Vivid-based Photo-Activatable Gal4 Transcription Factor in Mammalian Cells. Cell Struct Funct, 2022
  7. Expanding the molecular versatility of an optogenetic switch in yeast. Front Bioeng Biotechnol, 2022
  8. Implementation of a Novel Optogenetic Tool in Mammalian Cells Based on a Split T7 RNA Polymerase. ACS Synth Biol, 2022
  9. Light-switchable diphtherin transgene system combined with losartan for triple negtative breast cancer therapy based on nano drug delivery system. Int J Pharm, 2022
  10. Bifunctional optogenetic switch for improving shikimic acid production in E. coli. Biotechnol Biofuels, 2022
  11. Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins. Nat Biotechnol, 2022
  12. Opto-Katanin: An Optogenetic Tool for Localized Microtubule Disassembly. bioRxiv, 2021
  13. Modular and Molecular Optimization of a LOV (Light-Oxygen-Voltage)-Based Optogenetic Switch in Yeast. Int J Mol Sci, 2021
  14. Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells. J Vis Exp, 2021
  15. A Light-Oxygen-Voltage Receptor Integrates Light and Temperature. J Mol Biol, 2021
  16. Engineering AraC to make it responsive to light instead of arabinose. Nat Chem Biol, 2021
  17. Light-induced local gene expression in primary chick cell culture system. Dev Growth Differ, 2021
  18. A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nat Commun, 2021
  19. Photobiologically Directed Assembly of Gold Nanoparticles. Adv Biol, 2020
  20. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A, 2020
  21. Light-Regulated allosteric switch enables temporal and subcellular control of enzyme activity. Elife, 2020
  22. Spatiotemporal regulation of ubiquitin-mediated protein degradation via upconversion optogenetic nanosystem. Nano Res, 2020
  23. Photoactivatable oncolytic adenovirus for optogenetic cancer therapy. Cell Death Dis, 2020
  24. Orthogonal Blue and Red Light Controlled Cell-Cell Adhesions Enable Sorting-out in Multicellular Structures. ACS Synth Biol, 2020
  25. Targeted cell ablation in zebrafish using optogenetic transcriptional control. Development, 2020
  26. A Light-Inducible Strain for Genome-Wide Histone Turnover Profiling in Neurospora crassa. Genetics, 2020
  27. A combination of LightOn gene expression system and tumor microenvironment-responsive nanoparticle delivery system for targeted breast cancer therapy. Acta Pharm Sin B, 2020
  28. An optimized toolbox for the optogenetic control of intracellular transport. J Cell Biol, 2020
  29. RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations. Nat Methods, 2020
  30. Light-Inducible Recombinases for Bacterial Optogenetics. ACS Synth Biol, 2020
  31. Coupling delay controls synchronized oscillation in the segmentation clock. Nature, 2020
  32. Noise-reducing optogenetic negative-feedback gene circuits in human cells. Nucleic Acids Res, 2019
  33. Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions. J Mol Biol, 2019
  34. Independent Blue and Red Light Triggered Narcissistic Self-Sorting Self-Assembly of Colloidal Particles. Small, 2019
  35. Direct observation and analysis of the dynamics of the photoresponsive transcription factor GAL4. Angew Chem Int Ed Engl, 2019
  36. A Single-Component Optogenetic System Allows Stringent Switch of Gene Expression in Yeast Cells. ACS Synth Biol, 2018
  37. Fungal Light-Oxygen-Voltage Domains for Optogenetic Control of Gene Expression and Flocculation in Yeast. MBio, 2018
  38. Near-infrared light-controlled systems for gene transcription regulation, protein targeting and spectral multiplexing. Nat Protoc, 2018
  39. An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions. J Vis Exp, 2018
  40. Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information. Genes Dev, 2017
  41. Near-infrared optogenetic pair for protein regulation and spectral multiplexing. Nat Chem Biol, 2017
  42. Engineered Photoactivatable Genetic Switches Based on the Bacterium Phage T7 RNA Polymerase. ACS Synth Biol, 2016
  43. A light-switchable bidirectional expression system in filamentous fungus Trichoderma reesei. J Biotechnol, 2016
  44. Light-induced Notch activity controls neurogenic and gliogenic potential of neural progenitors. Biochem Biophys Res Commun, 2016
  45. An extraordinary stringent and sensitive light-switchable gene expression system for bacterial cells. Cell Res, 2016
  46. A bacterial phytochrome-based optogenetic system controllable with near-infrared light. Nat Methods, 2016
  47. Rewiring Multidomain Protein Switches: Transforming a Fluorescent Zn(2+) Sensor into a Light-Responsive Zn(2+) Binding Protein. ACS Synth Biol, 2016
  48. Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light. Nucleic Acids Res, 2015
  49. A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes. Biochem Biophys Res Commun, 2015
  50. Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins. Nat Commun, 2015
  51. Orthogonal optogenetic triple-gene control in Mammalian cells. ACS Synth Biol, 2014
  52. Spatio-temporally precise activation of engineered receptor tyrosine kinases by light. EMBO J, 2014
  53. Light-mediated control of gene expression in filamentous fungus Trichoderma reesei. J Microbiol Methods, 2014
  54. Genetically engineered photoinducible homodimerization system with improved dimer-forming efficiency. ACS Chem Biol, 2014
  55. Fine tuning the LightOn light-switchable transgene expression system. Biochem Biophys Res Commun, 2013
  56. Multi-chromatic control of mammalian gene expression and signaling. Nucleic Acids Res, 2013
  57. Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods, 2012
  58. Engineered Cas9 extracellular vesicles as a novel gene editing tool. J Extracell Vesicles, 2022