VVD

Photoreceptor VVD
Binding partner /
Cofactor FMN or FAD
Source organism Neurospora crassa
Mode of action homodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time hours
Crystal structure of the VVD homodimer. (PDB ID: 3RH8)

VVD-derived switches:

Related original publications

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  1. Full-field exposure of larval zebrafish to narrow waveband LED light sources at defined power and energy for optogenetic applications. J Neurosci Methods, 2023
  2. Diya – a universal light illumination platform for multiwell plate cultures. iScience, 2023
  3. A biological camera that captures and stores images directly into DNA. Nat Commun, 2023
  4. OPTO-BLUE: An Integrated Bidirectional Optogenetic Lentiviral Platform for Controlled Light-Induced Gene Expression. Int J Mol Sci, 2023
  5. Controlling protein stability with SULI, a highly sensitive tag for stabilization upon light induction. Nat Commun, 2023
  6. A Single-Component Optogenetic Gal4-UAS System Allows Stringent Control of Gene Expression in Zebrafish and Drosophila. ACS Synth Biol, 2023
  7. An optogenetic toolkit for light-inducible antibiotic resistance. Nat Commun, 2023
  8. Spatiotemporally controllable diphtherin transgene system and neoantigen immunotherapy. J Control Release, 2023
  9. Coupling Cell Communication and Optogenetics: Implementation of a Light-Inducible Intercellular System in Yeast. ACS Synth Biol, 2022
  10. Enhancement of Vivid-based Photo-Activatable Gal4 Transcription Factor in Mammalian Cells. Cell Struct Funct, 2022
  11. Expanding the molecular versatility of an optogenetic switch in yeast. Front Bioeng Biotechnol, 2022
  12. Opto-katanin, an optogenetic tool for localized, microtubule disassembly. Curr Biol, 2022
  13. Implementation of a Novel Optogenetic Tool in Mammalian Cells Based on a Split T7 RNA Polymerase. ACS Synth Biol, 2022
  14. Light-switchable diphtherin transgene system combined with losartan for triple negtative breast cancer therapy based on nano drug delivery system. Int J Pharm, 2022
  15. Bifunctional optogenetic switch for improving shikimic acid production in E. coli. Biotechnol Biofuels, 2022
  16. Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins. Nat Biotechnol, 2022
  17. Opto-Katanin: An Optogenetic Tool for Localized Microtubule Disassembly. bioRxiv, 2021
  18. Modular and Molecular Optimization of a LOV (Light-Oxygen-Voltage)-Based Optogenetic Switch in Yeast. Int J Mol Sci, 2021
  19. Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells. J Vis Exp, 2021
  20. A Light-Oxygen-Voltage Receptor Integrates Light and Temperature. J Mol Biol, 2021
  21. Engineering AraC to make it responsive to light instead of arabinose. Nat Chem Biol, 2021
  22. Optimization of the Light-On system in a lentiviral platform to a light-controlled expression of genes in neurons. Electron J Biotechnol, 2021
  23. Light-induced local gene expression in primary chick cell culture system. Dev Growth Differ, 2021
  24. A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nat Commun, 2021
  25. Photobiologically Directed Assembly of Gold Nanoparticles. Adv Biol, 2020
  26. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A, 2020
  27. Light-Regulated allosteric switch enables temporal and subcellular control of enzyme activity. Elife, 2020
  28. Spatiotemporal regulation of ubiquitin-mediated protein degradation via upconversion optogenetic nanosystem. Nano Res, 2020
  29. Photoactivatable oncolytic adenovirus for optogenetic cancer therapy. Cell Death Dis, 2020
  30. Orthogonal Blue and Red Light Controlled Cell-Cell Adhesions Enable Sorting-out in Multicellular Structures. ACS Synth Biol, 2020
  31. Targeted cell ablation in zebrafish using optogenetic transcriptional control. Development, 2020
  32. A Light-Inducible Strain for Genome-Wide Histone Turnover Profiling in Neurospora crassa. Genetics, 2020
  33. A combination of LightOn gene expression system and tumor microenvironment-responsive nanoparticle delivery system for targeted breast cancer therapy. Acta Pharm Sin B, 2020
  34. An optimized toolbox for the optogenetic control of intracellular transport. J Cell Biol, 2020
  35. RecV recombinase system for in vivo targeted optogenomic modifications of single cells or cell populations. Nat Methods, 2020
  36. Light-Inducible Recombinases for Bacterial Optogenetics. ACS Synth Biol, 2020
  37. Coupling delay controls synchronized oscillation in the segmentation clock. Nature, 2020
  38. Noise-reducing optogenetic negative-feedback gene circuits in human cells. Nucleic Acids Res, 2019
  39. Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions. J Mol Biol, 2019
  40. Independent Blue and Red Light Triggered Narcissistic Self-Sorting Self-Assembly of Colloidal Particles. Small, 2019
  41. Direct observation and analysis of the dynamics of the photoresponsive transcription factor GAL4. Angew Chem Int Ed Engl, 2019
  42. A Single-Component Optogenetic System Allows Stringent Switch of Gene Expression in Yeast Cells. ACS Synth Biol, 2018
  43. Fungal Light-Oxygen-Voltage Domains for Optogenetic Control of Gene Expression and Flocculation in Yeast. MBio, 2018
  44. Near-infrared light-controlled systems for gene transcription regulation, protein targeting and spectral multiplexing. Nat Protoc, 2018
  45. An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions. J Vis Exp, 2018
  46. Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information. Genes Dev, 2017
  47. Near-infrared optogenetic pair for protein regulation and spectral multiplexing. Nat Chem Biol, 2017
  48. Engineered Photoactivatable Genetic Switches Based on the Bacterium Phage T7 RNA Polymerase. ACS Synth Biol, 2016
  49. A light-switchable bidirectional expression system in filamentous fungus Trichoderma reesei. J Biotechnol, 2016
  50. Light-induced Notch activity controls neurogenic and gliogenic potential of neural progenitors. Biochem Biophys Res Commun, 2016
  51. An extraordinary stringent and sensitive light-switchable gene expression system for bacterial cells. Cell Res, 2016
  52. A bacterial phytochrome-based optogenetic system controllable with near-infrared light. Nat Methods, 2016
  53. Rewiring Multidomain Protein Switches: Transforming a Fluorescent Zn(2+) Sensor into a Light-Responsive Zn(2+) Binding Protein. ACS Synth Biol, 2016
  54. Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light. Nucleic Acids Res, 2015
  55. A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes. Biochem Biophys Res Commun, 2015
  56. Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins. Nat Commun, 2015
  57. Orthogonal optogenetic triple-gene control in Mammalian cells. ACS Synth Biol, 2014
  58. Spatio-temporally precise activation of engineered receptor tyrosine kinases by light. EMBO J, 2014
  59. Light-mediated control of gene expression in filamentous fungus Trichoderma reesei. J Microbiol Methods, 2014
  60. Genetically engineered photoinducible homodimerization system with improved dimer-forming efficiency. ACS Chem Biol, 2014
  61. Fine tuning the LightOn light-switchable transgene expression system. Biochem Biophys Res Commun, 2013
  62. Multi-chromatic control of mammalian gene expression and signaling. Nucleic Acids Res, 2013
  63. Spatiotemporal control of gene expression by a light-switchable transgene system. Nat Methods, 2012
  64. Engineered Cas9 extracellular vesicles as a novel gene editing tool. J Extracell Vesicles, 2022