Photoreceptor PhoCl
Binding partner /
Cofactor none
Source organism Clavularia sp.
Mode of action photocleavage
Excitation wavelength 380 nm
Reversion wavelength irreversible switch
Excitation time minutes
Reversion time /
Crystal structure of PhoCl. (PDB ID: 7DNA)

Related original publications

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  1. A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release. bioRxiv, 2024
  2. PhoCoil: An Injectable and Photodegradable Single-component Recombinant Protein Hydrogel for Localized Therapeutic Cell Delivery. bioRxiv, 2024
  3. An optogenetic method for the controlled release of single molecules. Nat Methods, 2024
  4. A single-component, light-assisted uncaging switch for endoproteolytic release. Nat Chem Biol, 2023
  5. Fluorogenesis: Inducing Fluorescence in a Non-Fluorescent Protein Through Photoinduced Chromophore Transfer of a Genetically Encoded Chromophore. bioRxiv, 2023
  6. A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing. Nat Commun, 2022
  7. Optogenetic Protein Cleavage in Zebrafish Embryos. Chembiochem, 2022
  8. Gigavalent Display of Proteins on Monodisperse Polyacrylamide Hydrogels as a Versatile Modular Platform for Functional Assays and Protein Engineering. ACS Cent Sci, 2022
  9. Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry. Nat Commun, 2022
  10. Designer membraneless organelles sequester native factors for control of cell behavior. Nat Chem Biol, 2021
  11. Improved Photocleavable Proteins with Faster and More Efficient Dissociation. bioRxiv, 2020
  12. SPLIT: Stable Protein Coacervation using a Light Induced Transition. ACS Synth Biol, 2020
  13. Hydrogels With Tunable Mechanical Properties Based on Photocleavable Proteins. Front Chem, 2020
  14. Photocleavable Cadherin Inhibits Cell-to-Cell Mechanotransduction by Light. ACS Chem Biol, 2019
  15. Genetically Encoded Photocleavable Linkers for Patterned Protein Release from Biomaterials. J Am Chem Soc, 2019
  16. Optogenetic control with a photocleavable protein, PhoCl. Nat Methods, 2017
  17. Pyroptosis Induction and Visualization at the Single-Cell Level Using Optogenetics. Methods Mol Biol, 2023