Photoreceptor PhoCl
Binding partner /
Cofactor none
Source organism Clavularia sp.
Mode of action photocleavage
Excitation wavelength 380 nm
Reversion wavelength irreversible switch
Excitation time minutes
Reversion time /
Crystal structure of PhoCl. (PDB ID: 7DNA)

Related original publications

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  1. Fluorogenesis: Inducing Fluorescence in a Non-Fluorescent Protein Through Photoinduced Chromophore Transfer of a Genetically Encoded Chromophore. bioRxiv, 2023
  2. A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing. Nat Commun, 2022
  3. Optogenetic Protein Cleavage in Zebrafish Embryos. Chembiochem, 2022
  4. Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry. Nat Commun, 2022
  5. Gigavalent display of proteins on monodisperse polyacrylamide hydrogels as a versatile modular platform for functional assays and protein engineering. bioRxiv, 2021
  6. Designer membraneless organelles sequester native factors for control of cell behavior. Nat Chem Biol, 2021
  7. Improved Photocleavable Proteins with Faster and More Efficient Dissociation. bioRxiv, 2020
  8. SPLIT: Stable Protein Coacervation using a Light Induced Transition. ACS Synth Biol, 2020
  9. Hydrogels With Tunable Mechanical Properties Based on Photocleavable Proteins. Front Chem, 2020
  10. Photocleavable Cadherin Inhibits Cell-to-Cell Mechanotransduction by Light. ACS Chem Biol, 2019
  11. Genetically Encoded Photocleavable Linkers for Patterned Protein Release from Biomaterials. J Am Chem Soc, 2019
  12. Optogenetic control with a photocleavable protein, PhoCl. Nat Methods, 2017