TULIP

Photoreceptor LOVpep (AsLOV2–ePDZpeptide)
Binding partner ePDZ
Cofactor FMN
Source organism Avena sativa
Mode of action heterodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds to minutes (variants available)

Related original publications

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  1. Concept and considerations of a medical device: the active noise cancelling incubator. Front Pediatr, 2023
  2. A cytokinetic ring-driven cell rotation achieves Hertwig’s rule in early development. bioRxiv, 2023
  3. Engineering of bidirectional, cyanobacteriochrome-based light-inducible dimers (BICYCL)s. Nat Methods, 2023
  4. Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division. Nat Cell Biol, 2023
  5. Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude. Cell Rep, 2022
  6. The effect of substrate stiffness on tensile force transduction in the epithelial monolayers. bioRxiv, 2021
  7. Light-inducible deformation of mitochondria in live cells. Cell Chem Biol, 2021
  8. Asymmetric Contraction of Adherens Junctions arises through RhoA and E-cadherin feedback. bioRxiv, 2021
  9. Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis. Elife, 2021
  10. Blue Light‐Operated CRISPR/Cas13b‐Mediated mRNA Knockdown (Lockdown). Adv Biol, 2021
  11. Correction to Lancet Infectious Diseases 2020; published online April 29. https://doi.org/10.1016/ S1473-3099(20)30064-5. Lancet Infect Dis, 2020
  12. Nano-positioning and tubuline conformation determine transport of mitochondria along microtubules. bioRxiv, 2020
  13. RhoA Mediates Epithelial Cell Shape Changes via Mechanosensitive Endocytosis. Dev Cell, 2019
  14. SapTrap Assembly of Caenorhabditis elegans MosSCI Transgene Vectors. G3 (Bethesda), 2019
  15. Mechanosensitive junction remodelling promotes robust epithelial morphogenesis. Lancet Diabetes Endocrinol, 2019
  16. Neurotrophin receptor tyrosine kinases regulated with near-infrared light. Nat Commun, 2019
  17. Guided by light: optogenetic control of microtubule gliding assays. Nano Lett, 2018
  18. Adherens junction-associated pores mediate the intercellular transport of endosomes and cytoplasmic proteins. Biochem Biophys Res Commun, 2018
  19. Optogenetic dissection of mitotic spindle positioning in vivo. Elife, 2018
  20. An Optogenetic approach to control protein localization during embryogenesis of the sea urchin. Dev Biol, 2018
  21. Engaging myosin VI tunes motility, morphology, and identity in endocytosis. Traffic, 2018
  22. Optogenetic interrogation of integrin αVβ3 function in endothelial cells. J Cell Sci, 2017
  23. Cell cycle entry triggers a switch between two modes of Cdc42 activation during yeast polarization. Elife, 2017
  24. Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres. Nat Commun, 2017
  25. A Phytochrome-Derived Photoswitch for Intracellular Transport. ACS Synth Biol, 2017
  26. Transcription activator-like effector-mediated regulation of gene expression based on the inducible packaging and delivery via designed extracellular vesicles. Biochem Biophys Res Commun, 2017
  27. Local RhoA activation induces cytokinetic furrows independent of spindle position and cell cycle stage. J Cell Biol, 2016
  28. Light-controlled intracellular transport in Caenorhabditis elegans. Curr Biol, 2016
  29. Correlating in Vitro and in Vivo Activities of Light-Inducible Dimers: A Cellular Optogenetics Guide. ACS Synth Biol, 2015
  30. Optogenetic control of organelle transport and positioning. Nature, 2015
  31. Benchmarking of optical dimerizer systems. ACS Synth Biol, 2014
  32. Orthogonal optogenetic triple-gene control in Mammalian cells. ACS Synth Biol, 2014
  33. TULIPs: tunable, light-controlled interacting protein tags for cell biology. Nat Methods, 2012
  34. Optogenetic Control of RhoA to Probe Subcellular Mechanochemical Circuitry. Curr Protoc Cell Biol, 2020