TULIP

Photoreceptor LOVpep (AsLOV2–ePDZpeptide)
Binding partner ePDZ
Cofactor FMN
Source organism Avena sativa
Mode of action heterodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds to minutes (variants available)

Related original publications

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  1. RhoA Mediates Epithelial Cell Shape Changes via Mechanosensitive Endocytosis. Dev Cell, 2019
  2. SapTrap Assembly of Caenorhabditis elegans MosSCI Transgene Vectors. G3 (Bethesda), 2019
  3. Mechanosensitive junction remodelling promotes robust epithelial morphogenesis. Lancet Diabetes Endocrinol, 2019
  4. Neurotrophin receptor tyrosine kinases regulated with near-infrared light. Nat Commun, 2019
  5. Guided by light: optogenetic control of microtubule gliding assays. Nano Lett, 2018
  6. Adherens junction-associated pores mediate the intercellular transport of endosomes and cytoplasmic proteins. Biochem Biophys Res Commun, 2018
  7. Optogenetic dissection of mitotic spindle positioning in vivo. Elife, 2018
  8. An Optogenetic approach to control protein localization during embryogenesis of the sea urchin. Dev Biol, 2018
  9. Engaging myosin VI tunes motility, morphology, and identity in endocytosis. Traffic, 2018
  10. Optogenetic interrogation of integrin αVβ3 function in endothelial cells. J Cell Sci, 2017
  11. Cell cycle entry triggers a switch between two modes of Cdc42 activation during yeast polarization. Elife, 2017
  12. Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres. Nat Commun, 2017
  13. A Phytochrome-Derived Photoswitch for Intracellular Transport. ACS Synth Biol, 2017
  14. Transcription activator-like effector-mediated regulation of gene expression based on the inducible packaging and delivery via designed extracellular vesicles. Biochem Biophys Res Commun, 2017
  15. Positioning the cleavage furrow: All you need is Rho. J Cell Biol, 2016
  16. Light-controlled intracellular transport in Caenorhabditis elegans. Curr Biol, 2016
  17. Correlating in Vitro and in Vivo Activities of Light-Inducible Dimers: A Cellular Optogenetics Guide. ACS Synth Biol, 2015
  18. Optogenetic control of organelle transport and positioning. Nature, 2015
  19. Benchmarking of optical dimerizer systems. ACS Synth Biol, 2014
  20. Orthogonal optogenetic triple-gene control in Mammalian cells. ACS Synth Biol, 2014
  21. TULIPs: tunable, light-controlled interacting protein tags for cell biology. Nat Methods, 2012
  22. Optogenetic Control of RhoA to Probe Subcellular Mechanochemical Circuitry. Curr Protoc Cell Biol, 2020