CRY2/CIB1

Photoreceptor CRY2
Binding partner CIB1
Cofactor FAD
Source organism Arabidopsis thaliana
Mode of action heterodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes
Crystal structure of CRY2, without CIB1. (PDB ID: 6K8I)

Related original publications

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  1. Light-dependent modulation of protein localization and function in living bacteria cells. bioRxiv, 2022
  2. Upregulated flotillins and sphingosine kinase 2 derail AXL vesicular traffic to promote epithelial-mesenchymal transition. J Cell Sci, 2022
  3. An optogenetic tool to recruit individual PKC isozymes to the cell surface and promote specific phosphorylation of membrane proteins. J Biol Chem, 2022
  4. Optogenetic Control of PIP2 Interactions Shaping ENaC Activity. Int J Mol Sci, 2022
  5. Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis. bioRxiv, 2022
  6. Cell size and actin architecture determine force generation in optogenetically activated adherent cells. bioRxiv, 2022
  7. Spindle reorientation in response to mechanical stress is an emergent property of the spindle positioning mechanisms. bioRxiv, 2022
  8. Spatio-temporal, optogenetic control of gene expression in organoids. bioRxiv, 2022
  9. Mechanical strain stimulates COPII-dependent trafficking via Rac1. bioRxiv, 2022
  10. Light-driven biological actuators to probe the rheology of 3D microtissues. bioRxiv, 2022
  11. Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins. Nat Biotechnol, 2022
  12. Optogenetic Manipulation of Cell Migration with High Spatiotemporal Resolution Using Lattice Lightsheet Microscopy. bioRxiv, 2022
  13. Cell polarity determinant Dlg1 facilitates epithelial invagination by promoting tissue-scale mechanical coordination. bioRxiv, 2021
  14. CeLINC, a fluorescence-based protein-protein interaction assay in Caenorhabditis elegans. Genetics, 2021
  15. Optogenetic dissection of the roles of actomyosin in the mechanics underlying tissue fluidity. bioRxiv, 2021
  16. Nano-optogenetic engineering of CAR T cells for precision immunotherapy with enhanced safety. Nat Nanotechnol, 2021
  17. Microtubule disassembly by caspases is the rate-limiting step of cell extrusion bioRxiv, 2021
  18. Precise control of microtubule disassembly in living cells. bioRxiv, 2021
  19. An active tethering mechanism controls the fate of vesicles. Nat Commun, 2021
  20. Revisiting the Role of TGFβ Receptor Internalization for Smad Signaling: It is Not Required in Optogenetic TGFβ Signaling Systems. Adv Biol (Weinh), 2021
  21. Optogenetic Tools for Control of Public Goods in Saccharomyces cerevisiae. mSphere, 2021
  22. Mapping the dynamic transfer functions of eukaryotic gene regulation. Cell Syst, 2021
  23. Mechanical worrying drives cell migration in crowded environments. bioRxiv, 2021
  24. Rab11 endosomes coordinate centrosome number and movement following mitotic exit. bioRxiv, 2021
  25. Using optogenetics to link myosin patterns to contractile cell behaviors during convergent extension. Biophys J, 2021
  26. Light-inducible deformation of mitochondria in live cells. Cell Chem Biol, 2021
  27. Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival. Dev Cell, 2021
  28. Exosome-based delivery of super-repressor IκBα ameliorates kidney ischemia-reperfusion injury. Kidney Int, 2021
  29. Optogenetic Control of the Canonical Wnt Signaling Pathway During Xenopus laevis Embryonic Development. J Mol Biol, 2021
  30. Optical regulation of endogenous RhoA reveals selection of cellular responses by signal amplitude. bioRxiv, 2021
  31. Cell patterning by secretion-induced plasma membrane flows. bioRxiv, 2021
  32. PIP2 regulation of TRPC5 channel activation and desensitization. J Biol Chem, 2021
  33. Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis. bioRxiv, 2021
  34. Cell division in tissues enables macrophage infiltration. bioRxiv, 2021
  35. Optogenetic-based Localization of Talin to the Plasma Membrane Promotes Activation of β3 Integrins. J Biol Chem, 2021
  36. A modular tool to query and inducibly disrupt biomolecular condensates. Nat Commun, 2021
  37. A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch. Elife, 2021
  38. CRISPR-dcas9 Optogenetic Nanosystem for the Blue Light-Mediated Treatment of Neovascular Lesions. ACS Appl Bio Mater, 2021
  39. Transient light-activated gene expression in Chinese hamster ovary cells. BMC Biotechnol, 2021
  40. A CRISPR-Cas9-Based Near-Infrared Upconversion-Activated DNA Methylation Editing System. ACS Appl Mater Interfaces, 2021
  41. Transcription activation is enhanced by multivalent interactions independent of liquid-liquid phase separation. bioRxiv, 2021
  42. A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nat Commun, 2021
  43. Control of SRC molecular dynamics encodes distinct cytoskeletal responses by specifying signaling pathway usage. J Cell Sci, 2021
  44. Optogenetic Control of Phosphatidylinositol (3,4,5)‐triphosphate Production by Light‐sensitive Cryptochrome Proteins on the Plasma Membrane. Chin J Chem, 2021
  45. Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates interchromosomal movement. bioRxiv, 2021
  46. Optogenetic control of small GTPases reveals RhoA mediates intracellular calcium signaling. J Biol Chem, 2021
  47. Living materials with programmable functionalities grown from engineered microbial co-cultures. Nat Mater, 2021
  48. Synthetic gene networks recapitulate dynamic signal decoding and differential gene expression. bioRxiv, 2021
  49. A Light-Inducible Split-dCas9 System for Inhibiting the Progression of Bladder Cancer Cells by Activating p53 and E-cadherin. Front Mol Biosci, 2021
  50. Liquid-liquid phase separation of light-inducible transcription factors increases transcription activation in mammalian cells and mice. Sci Adv, 2021
  51. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A, 2020
  52. Regulating enzymatic reactions in Escherichia coli utilizing light-responsive cellular compartments based on liquid-liquid phase separation. bioRxiv, 2020
  53. Spatio-temporal Control of ERK Pulse Frequency Coordinates Fate Decisions during Mammary Acinar Morphogenesis. bioRxiv, 2020
  54. Single-Protein Tracking to Study Protein Interactions During Integrin-Based Migration. Methods Mol Biol, 2020
  55. Light-inducible Deformation of Mitochondria in Live Cells. bioRxiv, 2020
  56. Mechanical competition alters the cellular interpretation of an endogenous genetic programme. bioRxiv, 2020
  57. Multichromatic Control of Signaling Pathways in Mammalian Cells. Adv Biosyst, 2020
  58. Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila. Elife, 2020
  59. Control of Cell Migration Using Optogenetics. Methods Mol Biol, 2020
  60. Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast. Cells, 2020
  61. CL6mN: Rationally Designed Optogenetic Photoswitches with Tunable Dissociation Dynamics. ACS Synth Biol, 2020
  62. A non-invasive far-red light-induced split-Cre recombinase system for controllable genome engineering in mice. Nat Commun, 2020
  63. Photo-SNAP-tag, a Light-Regulated Chemical Labeling System. ACS Chem Biol, 2020
  64. Optogenetic Control of Gene Expression Using Cryptochrome 2 and a Light-Activated Degron. Methods Mol Biol, 2020
  65. βH-spectrin is required for ratcheting apical pulsatile constrictions during tissue invagination. EMBO Rep, 2020
  66. Early But Not Delayed Optogenetic RAF Activation Promotes Astrocytogenesis in Mouse Neural Progenitors. J Mol Biol, 2020
  67. Photoactivatable RNA N6 -Methyladenosine Editing with CRISPR-Cas13. Small, 2020
  68. Dual Function of PI(4,5)P2 in Insulin-Regulated Exocytic Trafficking of GLUT4 in Adipocytes. J Mol Biol, 2020
  69. ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization. Dev Cell, 2020
  70. CofActor: A light- and stress-gated optogenetic clustering tool to study disease-associated cytoskeletal dynamics in living cells. J Biol Chem, 2020
  71. Optical Activation of TrkB Signaling. J Mol Biol, 2020
  72. CLIC4 is a cytokinetic cleavage furrow protein that regulates cortical cytoskeleton stability during cell division. J Cell Sci, 2020
  73. Photoactivatable Cre recombinase 3.0 for in vivo mouse applications. Nat Commun, 2020
  74. Optogenetic stimulation of phosphoinositides reveals a critical role of primary cilia in eye pressure regulation. Sci Adv, 2020
  75. Phosphatidylinositol 4,5-bisphosphate directly interacts with the β and γ subunits of the sodium channel ENaC. J Biol Chem, 2020
  76. Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality. Sci Adv, 2020
  77. A Generalizable Optogenetic Strategy to Regulate Receptor Tyrosine Kinases during Vertebrate Embryonic Development. J Mol Biol, 2020
  78. Cytokinetic bridge triggers de novo lumen formation in vivo. Nat Commun, 2020
  79. Tissue-Scale Mechanical Coupling Reduces Morphogenetic Noise to Ensure Precision during Epithelial Folding. Dev Cell, 2020
  80. Spatiotemporal control of phosphatidic acid signaling with optogenetic, engineered phospholipase Ds. J Cell Biol, 2020
  81. Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation. J Cell Biol, 2020
  82. Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling. Nat Commun, 2020
  83. Engineering light-controllable CAR T cells for cancer immunotherapy. Sci Adv, 2020
  84. Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage. Cell Rep, 2020
  85. Optogenetic control of mRNA localization and translation in live cells. Nat Cell Biol, 2020
  86. Cell and tissue manipulation with ultrashort infrared laser pulses in light-sheet microscopy. Sci Rep, 2020
  87. Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase. PLoS Biol, 2020
  88. Shape-morphing living composites. Sci Adv, 2020
  89. Tunable light and drug induced depletion of target proteins. Nat Commun, 2020
  90. Stick-slip dynamics of cell adhesion triggers spontaneous symmetry breaking and directional migration of mesenchymal cells on one-dimensional lines. Sci Adv, 2020
  91. Engineered BRET-Based Biologic Light Sources Enable Spatiotemporal Control over Diverse Optogenetic Systems. ACS Synth Biol, 2019
  92. Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models. Dev Cell, 2019
  93. Directed evolution improves the catalytic efficiency of TEV protease. Nat Methods, 2019
  94. Blue light-triggered optogenetic system for treating uveal melanoma. Oncogene, 2019
  95. A yeast optogenetic toolkit (yOTK) for gene expression control in Saccharomyces cerevisiae. Biotechnol Bioeng, 2019
  96. Optogenetic inhibition of Delta reveals digital Notch signaling output during tissue differentiation. EMBO Rep, 2019
  97. Imaging of Morphological and Biochemical Hallmarks of Apoptosis with Optimized Optogenetic Actuators. PLoS ONE, 2019
  98. Flotillins promote T cell receptor sorting through a fast Rab5-Rab11 endocytic recycling axis. Nat Commun, 2019
  99. Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs. Nat Biotechnol, 2019
  100. FRET-assisted photoactivation of flavoproteins for in vivo two-photon optogenetics. Nat Methods, 2019
  101. Secretory Vesicle Clustering in Fungal Filamentous Cells Does Not Require Directional Growth. Cell Rep, 2019
  102. Light-Induced Transcription Activation for Time-Lapse Microscopy Experiments in Living Cells. Methods Mol Biol, 2019
  103. Transient Activations of Rac1 at the Lamellipodium Tip Trigger Membrane Protrusion. Curr Biol, 2019
  104. Optogenetic gene editing in regional skin. Cell Res, 2019
  105. Achieving tight control of a photoactivatable Cre recombinase gene switch: new design strategies and functional characterization in mammalian cells and rodent. Nucleic Acids Res, 2019
  106. Cross-linker-mediated regulation of actin network organization controls tissue morphogenesis. J Cell Biol, 2019
  107. LADL: light-activated dynamic looping for endogenous gene expression control. Nat Methods, 2019
  108. OpEn-Tag-A Customizable Optogenetic Toolbox To Dissect Subcellular Signaling. ACS Synth Biol, 2019
  109. Accurate manipulation of optogenetic proteins with wavelength tunable femtosecond laser system. J Appl Phys, 2019
  110. Reversible Optogenetic Control of Growth Factor Signaling During Cell Differentiation and Vertebrate Embryonic Development. OSA Technical Digest, 2019
  111. Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos. Cell, 2019
  112. Cortical mitochondria regulate insulin secretion by local Ca2+ buffering. J Cell Sci, 2019
  113. Advances in optogenetic regulation of gene expression in mammalian cells using cryptochrome 2 (CRY2). Methods, 2019
  114. Optogenetic perturbation of the biochemical pathways that control cell behavior. Meth Enzymol, 2019
  115. Chapter Ten - Design, construction, and validation of optogenetic proteins. Lancet Diabetes Endocrinol, 2019
  116. Physical Plasma Membrane Perturbation Using Subcellular Optogenetics Drives Integrin-Activated Cell Migration. ACS Synth Biol, 2019
  117. Light-Induced Protein Clustering for Optogenetic Interference and Protein Interaction Analysis in Drosophila S2 Cells. Biomolecules, 2019
  118. Near-infrared light remotely up-regulate autophagy with spatiotemporal precision via upconversion optogenetic nanosystem. Biomaterials, 2019
  119. A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Neuron, 2019
  120. Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions. Nat Commun, 2019
  121. Blue Light Switchable Cell–Cell Interactions Provide Reversible and Spatiotemporal Control Towards Bottom-Up Tissue Engineering. Adv Biosyst, 2019
  122. Enhanced intrinsic CYP3A4 activity in human hepatic C3A cells with optically controlled CRISPR/dCas9 activator complex. Integr Biol (Camb), 2018
  123. Development of a Wireless-Controlled LED Array for the Tunable Optogenetic Control of Cellular Activities. Engineering, 2018
  124. Optogenetic dissection of Rac1 and Cdc42 gradient shaping. Nat Commun, 2018
  125. Downregulation of basal myosin-II is required for cell shape changes and tissue invagination. EMBO J, 2018
  126. Membrane dynamics induced by a PIP3 optogenetic tool. Anal Sci, 2018
  127. Real-Time Genetic Compensation Defines the Dynamic Demands of Feedback Control. Cell, 2018
  128. RalB directly triggers invasion downstream Ras by mobilizing the Wave complex. Elife, 2018
  129. Light Control of the Tet Gene Expression System in Mammalian Cells. Cell Rep, 2018
  130. Optogenetic control of epithelial-mesenchymal transition in cancer cells. Sci Rep, 2018
  131. A Single-Component Optogenetic System Allows Stringent Switch of Gene Expression in Yeast Cells. ACS Synth Biol, 2018
  132. Spatiotemporal control of zebrafish (Danio rerio) gene expression using a light-activated CRISPR activation system. Gene, 2018
  133. Optical activation of TrkA signaling. ACS Synth Biol, 2018
  134. Synthetic far-red light-mediated CRISPR-dCas9 device for inducing functional neuronal differentiation. Proc Natl Acad Sci USA, 2018
  135. Guided morphogenesis through optogenetic activation of Rho signalling during early Drosophila embryogenesis. Nat Commun, 2018
  136. Independent Control over Multiple Cell Types in Space and Time Using Orthogonal Blue and Red Light Switchable Cell Interactions. Adv Sci, 2018
  137. A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging. Sci Rep, 2018
  138. Regulation of cell cycle progression by cell-cell and cell-matrix forces. Nat Cell Biol, 2018
  139. Optogenetic inhibition of Gαq protein signaling reduces calcium oscillation stochasticity. ACS Synth Biol, 2018
  140. A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation. Nat Commun, 2018
  141. Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep, 2018
  142. A biochemical network controlling basal myosin oscillation. Nat Commun, 2018
  143. Optogenetic Control of Cell Migration. Methods Mol Biol, 2018
  144. Light-activated protein interaction with high spatial subcellular confinement. Proc Natl Acad Sci USA, 2018
  145. Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy. ACS Chem Biol, 2018
  146. Unique Roles of β-Arrestin in GPCR Trafficking Revealed by Photoinducible Dimerizers. Sci Rep, 2018
  147. Spatiotemporal Control of TGF-β Signaling with Light. ACS Synth Biol, 2017
  148. Gradients of Rac1 Nanoclusters Support Spatial Patterns of Rac1 Signaling. Cell Rep, 2017
  149. Real-time observation of light-controlled transcription in living cells. J Cell Sci, 2017
  150. Optogenetic regulation of artificial microRNA improves H2 production in green alga Chlamydomonas reinhardtii. Biotechnol Biofuels, 2017
  151. Propagating Wave of ERK Activation Orients Collective Cell Migration. Dev Cell, 2017
  152. Near-Infrared Light Triggered Upconversion Optogenetic Nanosystem for Cancer Therapy. ACS Nano, 2017
  153. Design and Profiling of a Subcellular Targeted Optogenetic cAMP-Dependent Protein Kinase. Cell Chem Biol, 2017
  154. Optimized light-inducible transcription in mammalian cells using Flavin Kelch-repeat F-box1/GIGANTEA and CRY2/CIB1. Nucleic Acids Res, 2017
  155. A single-chain photoswitchable CRISPR-Cas9 architecture for light-inducible gene editing and transcription. ACS Chem Biol, 2017
  156. Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun, 2017
  157. CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation. Nat Methods, 2017
  158. Two independent but synchronized Gβγ subunit-controlled pathways are essential for trailing-edge retraction during macrophage migration. J Biol Chem, 2017
  159. Photo-Activatable Akt Probe - A New Tool to Study the Akt-Dependent Physiopathology of Cancer Cells. Oncol Res, 2017
  160. An Engineered Optogenetic Switch for Spatiotemporal Control of Gene Expression, Cell Differentiation, and Tissue Morphogenesis. ACS Synth Biol, 2017
  161. Vesicle Docking Is a Key Target of Local PI(4,5)P2 Metabolism in the Secretory Pathway of INS-1 Cells. Cell Rep, 2017
  162. A calcium- and light-gated switch to induce gene expression in activated neurons. Nat Biotechnol, 2017
  163. Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts. Nat Commun, 2017
  164. Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development. J Vis Exp, 2017
  165. Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2. Nucleic Acids Res, 2017
  166. Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation. Nat Commun, 2017
  167. Temporally precise labeling and control of neuromodulatory circuits in the mammalian brain. Nat Methods, 2017
  168. Light-Regulated Protein Kinases Based on the CRY2-CIB1 System. Methods Mol Biol, 2017
  169. Optogenetic control of cellular forces and mechanotransduction. Nat Commun, 2017
  170. Epigenetic Editing of Ascl1 Gene in Neural Stem Cells by Optogenetics. Sci Rep, 2017
  171. Optogenetic Control of Synaptic Composition and Function. Neuron, 2017
  172. Transcription activator-like effector-mediated regulation of gene expression based on the inducible packaging and delivery via designed extracellular vesicles. Biochem Biophys Res Commun, 2017
  173. A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation. ACS Chem Biol, 2016
  174. Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis. Cell Rep, 2016
  175. Optogenetic inhibition of apical constriction during Drosophila embryonic development. Methods Cell Biol, 2016
  176. An open-hardware platform for optogenetics and photobiology. Sci Rep, 2016
  177. A photoactivatable Cre-loxP recombination system for optogenetic genome engineering. Nat Chem Biol, 2016
  178. Reversible optogenetic control of kinase activity during differentiation and embryonic development. Development, 2016
  179. Optogenetic regulation of site-specific subtelomeric DNA methylation. Oncotarget, 2016
  180. Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module. Nat Commun, 2016
  181. Using HEK293T Expression System to Study Photoactive Plant Cryptochromes. Front Plant Sci, 2016
  182. The Timing of Raf/ERK and AKT Activation in Protecting PC12 Cells against Oxidative Stress. PLoS ONE, 2016
  183. Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action. J Cell Sci, 2016
  184. Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase. Nat Chem Biol, 2016
  185. Optogenetic oligomerization of Rab GTPases regulates intracellular membrane trafficking. Nat Chem Biol, 2016
  186. Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors. Sci Rep, 2016
  187. Frequency and amplitude control of cortical oscillations by phosphoinositide waves. Nat Chem Biol, 2016
  188. An Optogenetic Method to Modulate Cell Contractility during Tissue Morphogenesis. Dev Cell, 2015
  189. Predictive Spatiotemporal Manipulation of Signaling Perturbations Using Optogenetics. Biophys J, 2015
  190. Correlating in Vitro and in Vivo Activities of Light-Inducible Dimers: A Cellular Optogenetics Guide. ACS Synth Biol, 2015
  191. An optogenetic system for interrogating the temporal dynamics of Akt. Sci Rep, 2015
  192. Optogenetic Control of Gene Expression in Drosophila. PLoS ONE, 2015
  193. Photo-activatable Cre recombinase regulates gene expression in vivo. Sci Rep, 2015
  194. Optogenetic apoptosis: light-triggered cell death. Angew Chem Int Ed Engl, 2015
  195. Photoactivatable CRISPR-Cas9 for optogenetic genome editing. Nat Biotechnol, 2015
  196. The Dual Characteristics of Light-Induced Cryptochrome 2, Homo-oligomerization and Heterodimerization, for Optogenetic Manipulation in Mammalian Cells. ACS Synth Biol, 2015
  197. Optogenetic control of molecular motors and organelle distributions in cells. Chem Biol, 2015
  198. A light-inducible CRISPR-Cas9 system for control of endogenous gene activation. Nat Chem Biol, 2015
  199. CRISPR-Cas9-based photoactivatable transcription system. Chem Biol, 2015
  200. Optogenetic control of organelle transport and positioning. Nature, 2015
  201. Single-molecule tracking of small GTPase Rac1 uncovers spatial regulation of membrane translocation and mechanism for polarized signaling. Proc Natl Acad Sci USA, 2015
  202. Benchmarking of optical dimerizer systems. ACS Synth Biol, 2014
  203. Engineered UV-A light-responsive gene expression system for measuring sun cream efficacy in mammalian cell culture. J Biotechnol, 2014
  204. Optogenetic engineering: light-directed cell motility. Angew Chem Int Ed Engl, 2014
  205. Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration. Mol Biol Cell, 2014
  206. Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling. Nat Commun, 2014
  207. Reversible protein inactivation by optogenetic trapping in cells. Nat Methods, 2014
  208. Bidirectional regulation of mRNA translation in mammalian cells by using PUF domains. Angew Chem Int Ed Engl, 2014
  209. Light-mediated kinetic control reveals the temporal effect of the Raf/MEK/ERK pathway in PC12 cell neurite outgrowth. PLoS ONE, 2014
  210. Real-time optogenetic control of intracellular protein concentration in microbial cell cultures. Integr Biol (Camb), 2014
  211. Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation. Mol Cell, 2013
  212. Light-inducible activation of target mRNA translation in mammalian cells. Chem Commun (Camb), 2013
  213. Optical control of mammalian endogenous transcription and epigenetic states. Nature, 2013
  214. Optogenetic control of PIP3: PIP3 is sufficient to induce the actin-based active part of growth cones and is regulated via endocytosis. PLoS ONE, 2013
  215. Live imaging of multicolor-labeled cells in Drosophila. Development, 2013
  216. Optogenetic control of transcription in zebrafish. PLoS ONE, 2012
  217. Light-mediated control of DNA transcription in yeast. Methods, 2012
  218. Optogenetic control of phosphoinositide metabolism. Proc Natl Acad Sci USA, 2012
  219. Rapid blue-light-mediated induction of protein interactions in living cells. Nat Methods, 2010
  220. Quantitative Analysis of Membrane Receptor Trafficking Manipulated by Optogenetic Tools. Methods Mol Biol, 2021