CRY2/CIB1

Photoreceptor CRY2
Binding partner CIB1
Cofactor FAD
Source organism Arabidopsis thaliana
Mode of action heterodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes

Related original publications

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  1. Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy. ACS Chem Biol, 2018
  2. Unique Roles of β-Arrestin in GPCR Trafficking Revealed by Photoinducible Dimerizers. Sci Rep, 2018
  3. Spatiotemporal Control of TGF-β Signaling with Light. ACS Synth Biol, 2017
  4. Gradients of Rac1 Nanoclusters Support Spatial Patterns of Rac1 Signaling. Cell Rep, 2017
  5. Real-time observation of light-controlled transcription in living cells. J Cell Sci, 2017
  6. Optogenetic regulation of artificial microRNA improves H2 production in green alga Chlamydomonas reinhardtii. Biotechnol Biofuels, 2017
  7. Propagating Wave of ERK Activation Orients Collective Cell Migration. Dev Cell, 2017
  8. Near-Infrared Light Triggered Upconversion Optogenetic Nanosystem for Cancer Therapy. ACS Nano, 2017
  9. Design and Profiling of a Subcellular Targeted Optogenetic cAMP-Dependent Protein Kinase. Cell Chem Biol, 2017
  10. Optimized light-inducible transcription in mammalian cells using Flavin Kelch-repeat F-box1/GIGANTEA and CRY2/CIB1. Nucleic Acids Res, 2017
  11. A single-chain photoswitchable CRISPR-Cas9 architecture for light-inducible gene editing and transcription. ACS Chem Biol, 2017
  12. Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun, 2017
  13. CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation. Nat Methods, 2017
  14. Two independent but synchronized Gβγ subunit-controlled pathways are essential for trailing-edge retraction during macrophage migration. J Biol Chem, 2017
  15. Photo-Activatable Akt Probe - A New Tool to Study the Akt-Dependent Physiopathology of Cancer Cells. Oncol Res, 2017
  16. An Engineered Optogenetic Switch for Spatiotemporal Control of Gene Expression, Cell Differentiation, and Tissue Morphogenesis. ACS Synth Biol, 2017
  17. Vesicle Docking Is a Key Target of Local PI(4,5)P2 Metabolism in the Secretory Pathway of INS-1 Cells. Cell Rep, 2017
  18. A calcium- and light-gated switch to induce gene expression in activated neurons. Nat Biotechnol, 2017
  19. Optogenetic activation of Plexin-B1 reveals contact repulsion between osteoclasts and osteoblasts. Nat Commun, 2017
  20. Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development. J Vis Exp, 2017
  21. Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2. Nucleic Acids Res, 2017
  22. Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation. Nat Commun, 2017
  23. Light-Regulated Protein Kinases Based on the CRY2-CIB1 System. Methods Mol Biol, 2017
  24. Optogenetic control of cellular forces and mechanotransduction. Nat Commun, 2017
  25. Epigenetic Editing of Ascl1 Gene in Neural Stem Cells by Optogenetics. Sci Rep, 2017
  26. Optogenetic Control of Synaptic Composition and Function. Neuron, 2017
  27. Transcription activator-like effector-mediated regulation of gene expression based on the inducible packaging and delivery via designed extracellular vesicles. Biochem Biophys Res Commun, 2017
  28. A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation. ACS Chem Biol, 2016
  29. Plasma Membrane Association but Not Midzone Recruitment of RhoGEF ECT2 Is Essential for Cytokinesis. Cell Rep, 2016
  30. Optogenetic inhibition of apical constriction during Drosophila embryonic development. Methods Cell Biol, 2016
  31. An open-hardware platform for optogenetics and photobiology. Sci Rep, 2016
  32. A photoactivatable Cre-loxP recombination system for optogenetic genome engineering. Nat Chem Biol, 2016
  33. Reversible optogenetic control of kinase activity during differentiation and embryonic development. Development, 2016
  34. Optogenetic regulation of site-specific subtelomeric DNA methylation. Oncotarget, 2016
  35. Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module. Nat Commun, 2016
  36. Using HEK293T Expression System to Study Photoactive Plant Cryptochromes. Front Plant Sci, 2016
  37. The Timing of Raf/ERK and AKT Activation in Protecting PC12 Cells against Oxidative Stress. PLoS ONE, 2016
  38. Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action. J Cell Sci, 2016
  39. Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase. Nat Chem Biol, 2016
  40. Optogenetic oligomerization of Rab GTPases regulates intracellular membrane trafficking. Nat Chem Biol, 2016
  41. Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors. Sci Rep, 2016
  42. Frequency and amplitude control of cortical oscillations by phosphoinositide waves. Nat Chem Biol, 2016
  43. An Optogenetic Method to Modulate Cell Contractility during Tissue Morphogenesis. Dev Cell, 2015
  44. Predictive Spatiotemporal Manipulation of Signaling Perturbations Using Optogenetics. Biophys J, 2015
  45. Correlating in Vitro and in Vivo Activities of Light-Inducible Dimers: A Cellular Optogenetics Guide. ACS Synth Biol, 2015
  46. An optogenetic system for interrogating the temporal dynamics of Akt. Sci Rep, 2015
  47. Optogenetic Control of Gene Expression in Drosophila. PLoS ONE, 2015
  48. Photo-activatable Cre recombinase regulates gene expression in vivo. Sci Rep, 2015
  49. Optogenetic apoptosis: light-triggered cell death. Angew Chem Int Ed Engl, 2015
  50. Photoactivatable CRISPR-Cas9 for optogenetic genome editing. Nat Biotechnol, 2015
  51. The Dual Characteristics of Light-Induced Cryptochrome 2, Homo-oligomerization and Heterodimerization, for Optogenetic Manipulation in Mammalian Cells. ACS Synth Biol, 2015
  52. Optogenetic control of molecular motors and organelle distributions in cells. Chem Biol, 2015
  53. A light-inducible CRISPR-Cas9 system for control of endogenous gene activation. Nat Chem Biol, 2015
  54. CRISPR-Cas9-based photoactivatable transcription system. Chem Biol, 2015
  55. Optogenetic control of organelle transport and positioning. Nature, 2015
  56. Single-molecule tracking of small GTPase Rac1 uncovers spatial regulation of membrane translocation and mechanism for polarized signaling. Proc Natl Acad Sci USA, 2015
  57. Benchmarking of optical dimerizer systems. ACS Synth Biol, 2014
  58. Engineered UV-A light-responsive gene expression system for measuring sun cream efficacy in mammalian cell culture. J Biotechnol, 2014
  59. Optogenetic engineering: light-directed cell motility. Angew Chem Int Ed Engl, 2014
  60. Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration. Mol Biol Cell, 2014
  61. Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling. Nat Commun, 2014
  62. Reversible protein inactivation by optogenetic trapping in cells. Nat Methods, 2014
  63. Bidirectional regulation of mRNA translation in mammalian cells by using PUF domains. Angew Chem Int Ed Engl, 2014
  64. Light-mediated kinetic control reveals the temporal effect of the Raf/MEK/ERK pathway in PC12 cell neurite outgrowth. PLoS ONE, 2014
  65. Real-time optogenetic control of intracellular protein concentration in microbial cell cultures. Integr Biol (Camb), 2014
  66. Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation. Mol Cell, 2013
  67. Light-inducible activation of target mRNA translation in mammalian cells. Chem Commun (Camb), 2013
  68. Optical control of mammalian endogenous transcription and epigenetic states. Nature, 2013
  69. Optogenetic control of PIP3: PIP3 is sufficient to induce the actin-based active part of growth cones and is regulated via endocytosis. PLoS ONE, 2013
  70. Optogenetic control of transcription in zebrafish. PLoS ONE, 2012
  71. Light-mediated control of DNA transcription in yeast. Methods, 2012
  72. Optogenetic control of phosphoinositide metabolism. Proc Natl Acad Sci USA, 2012
  73. Rapid blue-light-mediated induction of protein interactions in living cells. Nat Methods, 2010
  74. Live imaging of multicolor-labeled cells in Drosophila. Development, 2013