VfAU1-LOV

Photoreceptor VfAU1-LOV
Binding partner /
Cofactor FMN
Source organism Vaucheria frigida
Mode of action homodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes
Crystal structure of VfAU1-LOV, ground state. (PDB ID: 3UE6)

Related original publications

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  1. A nucleation barrier spring-loads the CBM signalosome for binary activation. bioRxiv, 2022
  2. Light-Inducible Spatio-Temporal Control of TLR4 and NF-κB-Gluc Reporter in Human Pancreatic Cell Line. Int J Mol Sci, 2021
  3. A Light-Oxygen-Voltage Receptor Integrates Light and Temperature. J Mol Biol, 2021
  4. Pathogenic ACVR1R206H activation by Activin A-induced receptor clustering and autophosphorylation. EMBO J, 2021
  5. Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease. PLoS Genet, 2021
  6. Light-regulated voltage-gated potassium channels for acute interrogation of channel function in neurons and behavior. PLoS ONE, 2021
  7. Optogenetic investigation of BMP target gene expression diversity. Elife, 2020
  8. Optogenetic Control of the BMP Signaling Pathway. ACS Synth Biol, 2020
  9. Optogenetically Controlled TrkA Activity Improves the Regenerative Capacity of Hair-Follicle-Derived Stem Cells to Differentiate into Neurons and Glia. Adv Biosyst, 2020
  10. Novel culture system via wirelessly controllable optical stimulation of the FGF signaling pathway for human and pig pluripotency. Biomaterials, 2020
  11. Design and Application of Light-Regulated Receptor Tyrosine Kinases. Methods Mol Biol, 2020
  12. Optical Activation of TrkB Signaling. J Mol Biol, 2020
  13. Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation. Elife, 2020
  14. A Generalizable Optogenetic Strategy to Regulate Receptor Tyrosine Kinases during Vertebrate Embryonic Development. J Mol Biol, 2020
  15. Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions. J Mol Biol, 2019
  16. Reversible Optogenetic Control of Growth Factor Signaling During Cell Differentiation and Vertebrate Embryonic Development. OSA Technical Digest, 2019
  17. Membrane-Associated, Not Cytoplasmic or Nuclear, FGFR1 Induces Neuronal Differentiation. Cells, 2019
  18. Optogenetic Delineation of Receptor Tyrosine Kinase Subcircuits in PC12 Cell Differentiation. Cell Chem Biol, 2018
  19. Target Sequence Recognition by a Light-Activatable Basic Leucine Zipper Factor, Photozipper. Biochemistry, 2018
  20. Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation. Cell Rep, 2016
  21. Light-assisted small-molecule screening against protein kinases. Nat Chem Biol, 2015
  22. Spatio-temporally precise activation of engineered receptor tyrosine kinases by light. EMBO J, 2014