VfAU1-LOV

Photoreceptor VfAU1-LOV
Binding partner /
Cofactor FMN
Source organism Vaucheria frigida
Mode of action homodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes
Crystal structure of VfAU1-LOV, ground state. (PDB ID: 3UE6)

Related original publications

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  1. A transgenic zebrafish for spatiotemporal optogenetic activation of FGF/ERK signaling. Biol Open, 2026
  2. Light-activated insulin receptor modulates neuronal plasticity and cerebellar-driven behavior. iScience, 2026
  3. An optogenetic toolkit for robust activation of FGF, BMP, & Nodal signaling in zebrafish. Dev Biol, 2026
  4. Munc18 modulates syntaxin phase separation to promote exocytosis. Nat Neurosci, 2025
  5. An optogenetic toolkit for robust activation of FGF, BMP, & Nodal signaling in zebrafish. bioRxiv, 2025
  6. Optogenetic control of Corynebacterium glutamicum gene expression. Nucleic Acids Res, 2024
  7. Optogenetic control of Nodal signaling patterns. bioRxiv, 2024
  8. Optogenetic manipulation of BMP signaling to drive chondrogenic differentiation of hPSCs. Cell Rep, 2023
  9. Optogenetic Signaling Activation in Zebrafish Embryos. J Vis Exp, 2023
  10. A nucleation barrier spring-loads the CBM signalosome for binary activation. Elife, 2022
  11. Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice. Life Sci Alliance, 2021
  12. Light-Inducible Spatio-Temporal Control of TLR4 and NF-κB-Gluc Reporter in Human Pancreatic Cell Line. Int J Mol Sci, 2021
  13. A Light-Oxygen-Voltage Receptor Integrates Light and Temperature. J Mol Biol, 2021
  14. Pathogenic ACVR1R206H activation by Activin A-induced receptor clustering and autophosphorylation. EMBO J, 2021
  15. Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease. PLoS Genet, 2021
  16. Light-regulated voltage-gated potassium channels for acute interrogation of channel function in neurons and behavior. PLoS ONE, 2021
  17. Optogenetic investigation of BMP target gene expression diversity. Elife, 2020
  18. Optogenetic Control of the BMP Signaling Pathway. ACS Synth Biol, 2020
  19. Optogenetically Controlled TrkA Activity Improves the Regenerative Capacity of Hair-Follicle-Derived Stem Cells to Differentiate into Neurons and Glia. Adv Biosyst, 2020
  20. Novel culture system via wirelessly controllable optical stimulation of the FGF signaling pathway for human and pig pluripotency. Biomaterials, 2020
  21. Design and Application of Light-Regulated Receptor Tyrosine Kinases. Methods Mol Biol, 2020
  22. Optical Activation of TrkB Signaling. J Mol Biol, 2020
  23. Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation. Elife, 2020
  24. A Generalizable Optogenetic Strategy to Regulate Receptor Tyrosine Kinases during Vertebrate Embryonic Development. J Mol Biol, 2020
  25. Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions. J Mol Biol, 2019
  26. Membrane-Associated, Not Cytoplasmic or Nuclear, FGFR1 Induces Neuronal Differentiation. Cells, 2019
  27. Optogenetic Delineation of Receptor Tyrosine Kinase Subcircuits in PC12 Cell Differentiation. Cell Chem Biol, 2018
  28. Target Sequence Recognition by a Light-Activatable Basic Leucine Zipper Factor, Photozipper. Biochemistry, 2018
  29. Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation. Cell Rep, 2016
  30. Light-assisted small-molecule screening against protein kinases. Nat Chem Biol, 2015
  31. Spatio-temporally precise activation of engineered receptor tyrosine kinases by light. EMBO J, 2014