bPAC (BlaC)

Photoreceptor bPAC (BlaC)
Binding partner /
Cofactor FAD or FMN
Source organism Beggiatoa sp.
Mode of action cAMP production
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time tens of seconds
Crystal structure of the bPAC homodimer, ground state. (PDB ID: 5MBE)

bPAC (BlaC)-derived switches:

Related original publications

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  1. Modulation of cyclic nucleotide-mediated cellular signaling and gene expression using photoactivated adenylyl cyclase as an optogenetic tool. Sci Rep, 2017
  2. Optogenetic regulation of insulin secretion in pancreatic β-cells. Sci Rep, 2017
  3. Fast cAMP Modulation of Neurotransmission via Neuropeptide Signals and Vesicle Loading. Curr Biol, 2017
  4. Model-guided optogenetic study of PKA signaling in budding yeast. Mol Biol Cell, 2016
  5. Structural insight into photoactivation of an adenylate cyclase from a photosynthetic cyanobacterium. Proc Natl Acad Sci USA, 2016
  6. The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling. Sci Signal, 2015
  7. Controlling fertilization and cAMP signaling in sperm by optogenetics. Elife, 2015
  8. Optogenetic elevation of endogenous glucocorticoid level in larval zebrafish. Front Neural Circuits, 2013
  9. Natural and engineered photoactivated nucleotidyl cyclases for optogenetic applications. J Biol Chem, 2010
  10. Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa. J Biol Chem, 2010