bPAC (BlaC)

Related original publications

1. Light-Mediated Enhancement of Glucose-Stimulated Insulin Release of Optogenetically Engineered Human Pancreatic Beta-Cells. ACS Synth Biol, 2024
2. Mapping the Cellular Distribution of an Optogenetic Protein Using a Light-Stimulation Grid Mapping the Cellular Distribution of an Optogenetic Protein Using a Light-Stimulation Grid. J Vis Exp, 2024
3. Live-cell fluorescence imaging and optogenetic control of PKA kinase activity in fission yeast Schizosaccharomyces pombe. bioRxiv, 2024
4. Neuropeptidergic regulation of neuromuscular signaling in larval zebrafish alters swimming behavior and synaptic transmission. bioRxiv, 2024
5. Lifelong molecular consequences of high Glucocorticoids exposure during development bioRxiv, 2024
6. Pathogen infection induces sickness behaviors by recruiting neuromodulatory systems linked to stress and satiety in C. elegans. bioRxiv, 2024
7. Optogenetic demonstration of the involvement of SMA-negative mural cells in the regulation of cerebral blood flow. Front Physiol, 2023
8. Rab3 mediates cyclic AMP-dependent presynaptic plasticity and olfactory learning. bioRxiv, 2023
9. An Integrated Optogenetic and Bioelectronic Platform for Regulating Cardiomyocyte Function. bioRxiv, 2023
10. Optogenetic manipulation of neuronal and cardiomyocyte functions in zebrafish using microbial rhodopsins and adenylyl cyclases. Elife, 2023
11. All-optical mapping of cAMP transport reveals rules of sub-cellular localization. bioRxiv, 2023
12. Optogenetic Stimulation Array for Confocal Microscopy Fast Transient Monitoring. TBioCAS, 2022
13. Photoactivated adenylyl cyclases attenuate sepsis-induced cardiomyopathy by suppressing macrophage-mediated inflammation. Front Immunol, 2022
14. GPCR-dependent spatiotemporal cAMP generation confers functional specificity in cardiomyocytes and cardiac responses. bioRxiv, 2022
15. A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation. EMBO Rep, 2022
16. Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation. bioRxiv, 2022
17. Morphogen Directed Coordination of GPCR Activity Promotes Primary Cilium Function for Downstream Signaling. bioRxiv, 2022
18. Hypothalamic dopamine neurons motivate mating through persistent cAMP signalling. Nature, 2021
19. Endosomal cAMP production broadly impacts the cellular phosphoproteome. J Biol Chem, 2021
20. mem-iLID, a fast and economic protein purification method. Biosci Rep, 2021
21. Endosomal cAMP production broadly impacts the cellular phosphoproteome. bioRxiv, 2021
22. Vertebrate cells differentially interpret ciliary and extraciliary cAMP. Cell, 2021
23. Optogenetic tools for manipulation of cyclic nucleotides, functionally coupled to CNG-channels. Br J Pharmacol, 2021
24. Optogenetic modulation of real-time nanoscale dynamics of HCN channels using photoactivated adenylyl cyclases. RSC Chem Biol, 2021
25. Light-Induced Change of Arginine Conformation Modulates the Rate of Adenosine Triphosphate to Cyclic Adenosine Monophosphate Conversion in the Optogenetic System Containing Photoactivated Adenylyl Cyclase. J Chem Inf Model, 2021
26. Optogenetic Modification of Pseudomonas aeruginosa Enables Controllable Twitching Motility and Host Infection. ACS Synth Biol, 2021
27. Biphasic Response of Protein Kinase A to Cyclic Adenosine Monophosphate Triggers Distinct Epithelial Phenotypes. bioRxiv, 2020
28. SynaptoPAC, an optogenetic tool for induction of presynaptic plasticity. J Neurochem, 2020
29. Dual Activation of cAMP Production Through Photostimulation or Chemical Stimulation. Methods Mol Biol, 2020
30. Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium. Elife, 2020
31. Optogenetic Manipulation of Postsynaptic cAMP Using a Novel Transgenic Mouse Line Enables Synaptic Plasticity and Enhances Depolarization Following Tetanic Stimulation in the Hippocampal Dentate Gyrus. Front Neural Circuits, 2020
32. Booster, a Red-Shifted Genetically Encoded Förster Resonance Energy Transfer (FRET) Biosensor Compatible with Cyan Fluorescent Protein/Yellow Fluorescent Protein-Based FRET Biosensors and Blue Light-Responsive Optogenetic Tools. ACS Sens, 2020
33. An optogenetic tool for induced protein stabilization based on the Phaeodactylum tricornutum aureochrome 1a LOV domain. J Mol Biol, 2020
34. Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models. Dev Cell, 2019
35. Amelioration of Diabetes in a Murine Model upon Transplantation of Pancreatic β-Cells with Optogenetic Control of Cyclic Adenosine Monophosphate. ACS Synth Biol, 2019
36. Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases. Cell Chem Biol, 2019
37. Using a Robust and Sensitive GFP-Based cGMP Sensor for Real Time Imaging in Intact Caenorhabditis elegans. Genetics, 2019
38. Cyclic Nucleotide-Specific Optogenetics Highlights Compartmentalization of the Sperm Flagellum into cAMP Microdomains. Cells, 2019
39. Luminescence-activated nucleotide cyclase regulates spatial and temporal cAMP synthesis. J Biol Chem, 2018
40. Potassium channel-based optogenetic silencing. Nat Commun, 2018
41. Synthetic Light-Activated Ion Channels for Optogenetic Activation and Inhibition. Front Neurosci, 2018
42. Modulation of cyclic nucleotide-mediated cellular signaling and gene expression using photoactivated adenylyl cyclase as an optogenetic tool. Sci Rep, 2017
43. Optogenetic regulation of insulin secretion in pancreatic β-cells. Sci Rep, 2017
44. Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging. Sci Rep, 2017
45. Fast cAMP Modulation of Neurotransmission via Neuropeptide Signals and Vesicle Loading. Curr Biol, 2017
46. Model-guided optogenetic study of PKA signaling in budding yeast. Mol Biol Cell, 2016
47. Structural insight into photoactivation of an adenylate cyclase from a photosynthetic cyanobacterium. Proc Natl Acad Sci USA, 2016
48. The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling. Sci Signal, 2015
49. Manipulation of Interrenal Cell Function in Developing Zebrafish Using Genetically Targeted Ablation and an Optogenetic Tool. Endocrinology, 2015
50. Controlling fertilization and cAMP signaling in sperm by optogenetics. Elife, 2015
51. Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans. Cell, 2013
52. Optogenetic elevation of endogenous glucocorticoid level in larval zebrafish. Front Neural Circuits, 2013
53. Natural and engineered photoactivated nucleotidyl cyclases for optogenetic applications. J Biol Chem, 2010
54. Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa. J Biol Chem, 2010