bPAC (BlaC)

Photoreceptor bPAC (BlaC)
Binding partner /
Cofactor FAD or FMN
Source organism Beggiatoa sp.
Mode of action cAMP production
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time tens of seconds
Crystal structure of the bPAC homodimer, ground state. (PDB ID: 5MBE)

bPAC (BlaC)-derived switches:

Related original publications

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  1. Luminescence-activated nucleotide cyclase regulates spatial and temporal cAMP synthesis. J Biol Chem, 2018
  2. Potassium channel-based optogenetic silencing. Nat Commun, 2018
  3. Synthetic Light-Activated Ion Channels for Optogenetic Activation and Inhibition. Front Neurosci, 2018
  4. Modulation of cyclic nucleotide-mediated cellular signaling and gene expression using photoactivated adenylyl cyclase as an optogenetic tool. Sci Rep, 2017
  5. Optogenetic regulation of insulin secretion in pancreatic β-cells. Sci Rep, 2017
  6. Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging. Sci Rep, 2017
  7. Fast cAMP Modulation of Neurotransmission via Neuropeptide Signals and Vesicle Loading. Curr Biol, 2017
  8. Model-guided optogenetic study of PKA signaling in budding yeast. Mol Biol Cell, 2016
  9. Structural insight into photoactivation of an adenylate cyclase from a photosynthetic cyanobacterium. Proc Natl Acad Sci USA, 2016
  10. The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling. Sci Signal, 2015
  11. Controlling fertilization and cAMP signaling in sperm by optogenetics. Elife, 2015
  12. Optogenetic elevation of endogenous glucocorticoid level in larval zebrafish. Front Neural Circuits, 2013
  13. Natural and engineered photoactivated nucleotidyl cyclases for optogenetic applications. J Biol Chem, 2010
  14. Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa. J Biol Chem, 2010