Fascinating research using organoids: Spatiotemporal, optogenetic control of gene expression in organoids.
More optogenetic research using organoids: Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation.
Paper of the Month August: Optogenetic clustering and membrane translocation of the BcLOV4 photoreceptor.
Fascinating research in combination with a little bit of fun:
Paper of the Month July: "A biological camera that captures and stores images directly into DNA."
Featured Paper: "Designer Condensates: A Toolkit for the Biomolecular Architect."
Optogenetics is a excellent method to control cell signaling!
Paper of the Month June: An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells.
Featured Paper: How to use optogenetics in engineered living materials (ELMs): Light-Regulated Pro-Angiogenic Engineered Living Materials.
Paper of the Month April: A light-inactivated degron: Controlling protein stability with SULI, a highly sensitive tag for stabilization upon light induction.
Paper of the Month March: Optogenetic closed-loop feedback control of the unfolded protein response optimizes protein production.
Featured Paper: Learn more about the optimization of protein/chemical production using optogenetics: Optogenetic regulation of engineered cellular metabolism for microbial chemical production.
Paper of the Month February: Engineering of bidirectional, cyanobacteriochrome-based light-inducible dimers (BICYCL).
Paper of the Month December: Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles.
Featured Paper: Learn more about optogenetic inactivation of proteins with the "LARIAT" tool.
Paper of the Month November: Patterned mechanical feedback establishes a global myosin gradient.
Featured Paper: First published application of an optogentic switch in Drosophila: Fast manipulation of cellular cAMP level by light in vivo.
Paper of the Month October: Optogenetic-controlled immunotherapeutic designer cells for post-surgical cancer immunotherapy.
Featured Paper: Another strategy to use Optogenetics for cancer immunotherapy: Near-Infrared Nano-Optogenetic Activation of Cancer Immunotherapy via Engineered Bacteria.
Paper of the Month September: Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis.Featured Paper: Develpment of the first optoRAF: Optogenetic control of protein kinase activity in mammalian cells.
Paper of the Month August: Review about Shedding light on current trends in molecular optogenetics.
Featured Paper: Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease, highlighted in the review above.
Featured Paper: Learn more about Signal transduction in light-oxygen-voltage receptors lacking the active-site glutamine.
Paper of the Month June: Development of the MagRed (DrBphP/Aff6_V18FΔN) switch: A red light-responsive photoswitch for deep tissue optogenetics.
Featured Paper: First application of the DrBphP switch: Neurotrophin receptor tyrosine kinases regulated with near-infrared light.
Using bioluminescence to activate optogenetic switches and for communication between cells:
Paper of the Month April: Synthetic cells with self-activating optogenetic proteins communicate with natural cells.
Paper of the Month March: A background paper on PhyB: Plant phytochrome B is an asymmetric dimer with unique signalling potential.
Featured Paper: An "Extracellular Optogenetics" application of PhyB/PIF6: Light-Induced Printing of Protein Structures on Membranes in Vitro.
We constantly adapt optoBase for the latest molecular optogenetic trends. Thus, the new application tag Extracellular optogenetics includes all publications in our database that
We hope that this new tag streamlines your search on optoBase and welcome suggestions for future tags. Your optoBase-team
PHYB/PIF-mediated gene transfer. Spatiotemporally confined red light-controlled gene delivery at single-cell resolution using adeno-associated viral vectors.
Paper of the Month November: Two-input protein logic gate for computation in living cells.
Featured Paper: Learn more about logic gates in optogenetics: High-performance chemical- and light-inducible recombinases in mammalian cells and mice.
Paper of the Month October: A light tunable differentiation system for the creation and control of consortia in yeast.
Featured Paper: Learn more about optogenetics in yeast: The rise and shine of yeast optogenetics.
Paper of the Month September: NIR light-responsive bacteria with live bio-glue coatings for precise colonization in the gut.
Featured Paper: Learn more about optogenetics in bacteria: Synthetic Biological Approaches for Optogenetics and Tools for Transcriptional Light-Control in Bacteria.
Paper of the month August: A guide to the optogenetic regulation of endogenous molecules.
Featured Paper: Learn more about RNA editing with the photoactivatable CRISPR-Cas13: Photoactivatable RNA N6-Methyladenosine Editing with CRISPR-Cas13.
Paper of the month May: Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering.
Featured Paper: Learn more about optogenetic tools based on LOV domains: LOVTRAP: an optogenetic system for photoinduced protein dissociation.
Paper of the month April: Optogenetic-based Localization of Talin to the Plasma Membrane Promotes Activation of β3 Integrins.
Featured Paper: Optogenetic interrogation of integrin αVβ3 function in endothelial cells. Try out our filter options to search for more integrin research papers.
Paper of the month March: For a broad overview over the field of Molecular Optogenetics: Steering Molecular Activity with Optogenetics: Recent Advances and Perspectives.
Research Highlights in December
We are happy to introduce the “Paper of the Month”, which highlights one outstanding research paper of the previous month. Furthermore, the OptoBase team chooses one additional, groundbreaking paper from our extensive, weekly updated database.
We are proud to announce that the paper presenting OptoBase got last week successfully published in ACS Synthetic Biology. If you refer to OptoBase in your work, please cite it as this publication!
Looking for optogenetic publications presenting a particular type of biological application(s)? The new tool, Find The Application, helps you find them instantly.
A FAQ section was added to improve the OptoBase usability.
Check out our new tool that helps you find the most suitable optogenetic switches for your upcoming project.
The set of switches with a predefined function was added to complete our collection of optogenetic switches.
Launch Version 1.0