EL222

Photoreceptor EL222
Binding partner /
Cofactor FMN
Source organism Erythrobacter litoralis
Mode of action homodimerization, DNA binding
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds
Crystal structure of EL222, ground state (i.e. monomer). (PDB ID: 3P7N)

Related original publications

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  1. Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons. bioRxiv, 2019
  2. An Open-Source Plate Reader. Biochemistry, 2018
  3. Programming the Dynamic Control of Bacterial Gene Expression with a Chimeric Ligand- and Light-Based Promoter System. ACS Synth Biol, 2018
  4. Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells. Sci Rep, 2018
  5. Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation. Nat Commun, 2018
  6. An Optogenetic Platform for Real-Time, Single-Cell Interrogation of Stochastic Transcriptional Regulation. Mol Cell, 2018
  7. Cell-free optogenetic gene expression system. ACS Synth Biol, 2018
  8. Optogenetic regulation of engineered cellular metabolism for microbial chemical production. Nature, 2018
  9. A calcium- and light-gated switch to induce gene expression in activated neurons. Nat Biotechnol, 2017
  10. TAEL: a zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control. Development, 2016
  11. Blue light-mediated transcriptional activation and repression of gene expression in bacteria. Nucleic Acids Res, 2016
  12. An optogenetic gene expression system with rapid activation and deactivation kinetics. Nat Chem Biol, 2014
  13. Blue light-induced dimerization of a bacterial LOV-HTH DNA-binding protein. Biochemistry, 2013