EL222

Photoreceptor EL222
Binding partner /
Cofactor FMN
Source organism Erythrobacter litoralis
Mode of action homodimerization, DNA binding
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds
Crystal structure of EL222, ground state (i.e. monomer). (PDB ID: 3P7N)

Related original publications

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  1. A Single-Component Blue Light-Induced System Based on EL222 in Yarrowia lipolytica. Int J Mol Sci, 2022
  2. Synthetic cells with self-activating optogenetic proteins communicate with natural cells. Nat Commun, 2022
  3. Synthetic gene networks recapitulate dynamic signal decoding and differential gene expression. Cell Syst, 2022
  4. Using single-cell models to predict the functionality of synthetic circuits at the population scale. Proc Natl Acad Sci U S A, 2022
  5. Systematic In Vivo Characterization of Fluorescent Protein Maturation in Budding Yeast. ACS Synth Biol, 2022
  6. Development of Optogenetic Dual-Switch System for Rewiring Metabolic Flux for Polyhydroxybutyrate Production. Molecules, 2022
  7. Design and Characterization of an Optogenetic System in Pichia pastoris. ACS Synth Biol, 2022
  8. A light tunable differentiation system for the creation and control of consortia in yeast. Nat Commun, 2021
  9. Rapid prototyping and design of cybergenetic single-cell controllers. Nat Commun, 2021
  10. Light-Induced GFP Expression in Zebrafish Embryos using the Optogenetic TAEL/C120 System. J Vis Exp, 2021
  11. The Neurospora crassa Inducible Q System Enables Simultaneous Optogenetic Amplification and Inversion in Saccharomyces cerevisiae for Bidirectional Control of Gene Expression. ACS Synth Biol, 2021
  12. Using single-cell models to predict the functionality of synthetic circuits at the population scale. bioRxiv, 2021
  13. Cellulosic biofuel production using emulsified simultaneous saccharification and fermentation (eSSF) with conventional and thermotolerant yeasts. Biotechnol Biofuels, 2021
  14. Engineered NIR light-responsive bacteria as anti-tumor agent for targeted and precise cancer therapy. Lancet Infect Dis, 2021
  15. A light tunable differentiation system for the creation and control of consortia in yeast. bioRxiv, 2021
  16. Bioluminescent Synthetic Cells Communicate with Natural Cells and Self-Activate Light-Responsive Proteins. bioRxiv, 2021
  17. Optogenetic Amplification Circuits for Light-Induced Metabolic Control. ACS Synth Biol, 2021
  18. Blue Light‐Operated CRISPR/Cas13b‐Mediated mRNA Knockdown (Lockdown). Adv Biol, 2021
  19. TAEL 2.0: An Improved Optogenetic Expression System for Zebrafish. Zebrafish, 2021
  20. Dynamical Modeling of Optogenetic Circuits in Yeast for Metabolic Engineering Applications. ACS Synth Biol, 2021
  21. Optogenetics in Sinorhizobium meliloti Enables Spatial Control of Exopolysaccharide Production and Biofilm Structure. ACS Synth Biol, 2021
  22. Synthetic gene networks recapitulate dynamic signal decoding and differential gene expression. bioRxiv, 2021
  23. An Optogenetic Platform to Dynamically Control the Stiffness of Collagen Hydrogels. ACS Biomater Sci Eng, 2020
  24. Engineering an Optogenetic CRISPRi Platform for Improved Chemical Production. ACS Synth Biol, 2020
  25. An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Development, 2020
  26. Design and Characterization of Rapid Optogenetic Circuits for Dynamic Control in Yeast Metabolic Engineering. ACS Synth Biol, 2020
  27. Optogenetic Downregulation of Protein Levels to Control Programmed Cell Death in Mammalian Cells with a Dual Blue-Light Switch. Methods Mol Biol, 2020
  28. Optogenetic control of gene expression in plants in the presence of ambient white light. Nat Methods, 2020
  29. Light-powered Escherichia coli cell division for chemical production. Nat Commun, 2020
  30. Blue Light-Directed Cell Migration, Aggregation, and Patterning. J Mol Biol, 2020
  31. Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons. PLoS ONE, 2020
  32. Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling. Nat Commun, 2020
  33. An Open-Source Plate Reader. Biochemistry, 2018
  34. Programming the Dynamic Control of Bacterial Gene Expression with a Chimeric Ligand- and Light-Based Promoter System. ACS Synth Biol, 2018
  35. Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells. Sci Rep, 2018
  36. Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation. Nat Commun, 2018
  37. An Optogenetic Platform for Real-Time, Single-Cell Interrogation of Stochastic Transcriptional Regulation. Mol Cell, 2018
  38. Cell-free optogenetic gene expression system. ACS Synth Biol, 2018
  39. Optogenetic regulation of engineered cellular metabolism for microbial chemical production. Nature, 2018
  40. A calcium- and light-gated switch to induce gene expression in activated neurons. Nat Biotechnol, 2017
  41. TAEL: a zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control. Development, 2016
  42. Blue light-mediated transcriptional activation and repression of gene expression in bacteria. Nucleic Acids Res, 2016
  43. An optogenetic gene expression system with rapid activation and deactivation kinetics. Nat Chem Biol, 2014
  44. Blue light-induced dimerization of a bacterial LOV-HTH DNA-binding protein. Biochemistry, 2013