EL222

Photoreceptor EL222
Binding partner /
Cofactor FMN
Source organism Erythrobacter litoralis
Mode of action homodimerization, DNA binding
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds
Crystal structure of EL222, ground state (i.e. monomer). (PDB ID: 3P7N)

Related original publications

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  1. Cell-free optogenetic gene expression system. ACS Synth Biol, 2018
  2. Optogenetic regulation of engineered cellular metabolism for microbial chemical production. Nature, 2018
  3. A calcium- and light-gated switch to induce gene expression in activated neurons. Nat Biotechnol, 2017
  4. TAEL: a zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control. Development, 2016
  5. Blue light-mediated transcriptional activation and repression of gene expression in bacteria. Nucleic Acids Res, 2016
  6. An optogenetic gene expression system with rapid activation and deactivation kinetics. Nat Chem Biol, 2014
  7. Blue light-induced dimerization of a bacterial LOV-HTH DNA-binding protein. Biochemistry, 2013