Photoreceptor EL222
Binding partner /
Cofactor FMN
Source organism Erythrobacter litoralis
Mode of action homodimerization, DNA binding
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time seconds
Crystal structure of EL222, ground state (i.e. monomer). (PDB ID: 3P7N)

Related original publications

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  1. A light tunable differentiation system for the creation and control of consortia in yeast. Nat Commun, 2021
  2. Rapid prototyping and design of cybergenetic single-cell controllers. Nat Commun, 2021
  3. Light-Induced GFP Expression in Zebrafish Embryos using the Optogenetic TAEL/C120 System. J Vis Exp, 2021
  4. The Neurospora crassa Inducible Q System Enables Simultaneous Optogenetic Amplification and Inversion in Saccharomyces cerevisiae for Bidirectional Control of Gene Expression. ACS Synth Biol, 2021
  5. Using single-cell models to predict the functionality of synthetic circuits at the population scale. bioRxiv, 2021
  6. A light tunable differentiation system for the creation and control of consortia in yeast. bioRxiv, 2021
  7. Bioluminescent Synthetic Cells Communicate with Natural Cells and Self-Activate Light-Responsive Proteins. bioRxiv, 2021
  8. Optogenetic Amplification Circuits for Light-Induced Metabolic Control. ACS Synth Biol, 2021
  9. Blue Light‐Operated CRISPR/Cas13b‐Mediated mRNA Knockdown (Lockdown). Adv Biol, 2021
  10. TAEL 2.0: An Improved Optogenetic Expression System for Zebrafish. Zebrafish, 2021
  11. Dynamical Modeling of Optogenetic Circuits in Yeast for Metabolic Engineering Applications. ACS Synth Biol, 2021
  12. Optogenetics in Sinorhizobium meliloti Enables Spatial Control of Exopolysaccharide Production and Biofilm Structure. ACS Synth Biol, 2021
  13. Synthetic gene networks recapitulate dynamic signal decoding and differential gene expression. bioRxiv, 2021
  14. Engineering an Optogenetic CRISPRi Platform for Improved Chemical Production. ACS Synth Biol, 2020
  15. Design and Characterization of Rapid Optogenetic Circuits for Dynamic Control in Yeast Metabolic Engineering. ACS Synth Biol, 2020
  16. Optogenetic Downregulation of Protein Levels to Control Programmed Cell Death in Mammalian Cells with a Dual Blue-Light Switch. Methods Mol Biol, 2020
  17. Requirement of Irf6 and Esrp1/2 in frontonasal and palatal epithelium to regulate craniofacial and palate morphogenesis in mouse and zebrafish. bioRxiv, 2020
  18. Optogenetic control of gene expression in plants in the presence of ambient white light. Nat Methods, 2020
  19. Light-powered Escherichia coli cell division for chemical production. Nat Commun, 2020
  20. Blue Light-Directed Cell Migration, Aggregation, and Patterning. J Mol Biol, 2020
  21. Optical induction of autophagy via Transcription factor EB (TFEB) reduces pathological tau in neurons. PLoS ONE, 2020
  22. Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling. Nat Commun, 2020
  23. An Open-Source Plate Reader. Biochemistry, 2018
  24. Programming the Dynamic Control of Bacterial Gene Expression with a Chimeric Ligand- and Light-Based Promoter System. ACS Synth Biol, 2018
  25. Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells. Sci Rep, 2018
  26. Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation. Nat Commun, 2018
  27. An Optogenetic Platform for Real-Time, Single-Cell Interrogation of Stochastic Transcriptional Regulation. Mol Cell, 2018
  28. Cell-free optogenetic gene expression system. ACS Synth Biol, 2018
  29. Optogenetic regulation of engineered cellular metabolism for microbial chemical production. Nature, 2018
  30. A calcium- and light-gated switch to induce gene expression in activated neurons. Nat Biotechnol, 2017
  31. TAEL: a zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control. Development, 2016
  32. Blue light-mediated transcriptional activation and repression of gene expression in bacteria. Nucleic Acids Res, 2016
  33. An optogenetic gene expression system with rapid activation and deactivation kinetics. Nat Chem Biol, 2014
  34. Blue light-induced dimerization of a bacterial LOV-HTH DNA-binding protein. Biochemistry, 2013