VfAU1-LOV

Photoreceptor VfAU1-LOV
Binding partner /
Cofactor FMN
Source organism Vaucheria frigida
Mode of action homodimerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes
Crystal structure of VfAU1-LOV, ground state. (PDB ID: 3UE6)

Related original publications

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  1. Munc18 modulates syntaxin phase separation to promote exocytosis. Nat Neurosci, 2025
  2. An optogenetic toolkit for robust activation of FGF, BMP, & Nodal signaling in zebrafish. bioRxiv, 2025
  3. Optogenetic control of Corynebacterium glutamicum gene expression. Nucleic Acids Res, 2024
  4. Optogenetic control of Nodal signaling patterns. bioRxiv, 2024
  5. Optogenetic manipulation of BMP signaling to drive chondrogenic differentiation of hPSCs. Cell Rep, 2023
  6. Optogenetic Signaling Activation in Zebrafish Embryos. J Vis Exp, 2023
  7. A nucleation barrier spring-loads the CBM signalosome for binary activation. Elife, 2022
  8. Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice. Life Sci Alliance, 2021
  9. Light-Inducible Spatio-Temporal Control of TLR4 and NF-κB-Gluc Reporter in Human Pancreatic Cell Line. Int J Mol Sci, 2021
  10. A Light-Oxygen-Voltage Receptor Integrates Light and Temperature. J Mol Biol, 2021
  11. Pathogenic ACVR1R206H activation by Activin A-induced receptor clustering and autophosphorylation. EMBO J, 2021
  12. Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease. PLoS Genet, 2021
  13. Light-regulated voltage-gated potassium channels for acute interrogation of channel function in neurons and behavior. PLoS ONE, 2021
  14. Optogenetic investigation of BMP target gene expression diversity. Elife, 2020
  15. Optogenetic Control of the BMP Signaling Pathway. ACS Synth Biol, 2020
  16. Optogenetically Controlled TrkA Activity Improves the Regenerative Capacity of Hair-Follicle-Derived Stem Cells to Differentiate into Neurons and Glia. Adv Biosyst, 2020
  17. Novel culture system via wirelessly controllable optical stimulation of the FGF signaling pathway for human and pig pluripotency. Biomaterials, 2020
  18. Design and Application of Light-Regulated Receptor Tyrosine Kinases. Methods Mol Biol, 2020
  19. Optical Activation of TrkB Signaling. J Mol Biol, 2020
  20. Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylation. Elife, 2020
  21. A Generalizable Optogenetic Strategy to Regulate Receptor Tyrosine Kinases during Vertebrate Embryonic Development. J Mol Biol, 2020
  22. Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein-Protein Interactions. J Mol Biol, 2019
  23. Membrane-Associated, Not Cytoplasmic or Nuclear, FGFR1 Induces Neuronal Differentiation. Cells, 2019
  24. Optogenetic Delineation of Receptor Tyrosine Kinase Subcircuits in PC12 Cell Differentiation. Cell Chem Biol, 2018
  25. Target Sequence Recognition by a Light-Activatable Basic Leucine Zipper Factor, Photozipper. Biochemistry, 2018
  26. Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation. Cell Rep, 2016
  27. Light-assisted small-molecule screening against protein kinases. Nat Chem Biol, 2015
  28. Spatio-temporally precise activation of engineered receptor tyrosine kinases by light. EMBO J, 2014