CRY2olig

Photoreceptor CRY2olig
Binding partner /
Cofactor FAD
Source organism Arabidopsis thaliana
Mode of action homooligomerization
Excitation wavelength 450 nm
Reversion wavelength dark
Excitation time seconds
Reversion time minutes

Related original publications

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  1. RNA G-quadruplexes form scaffolds that promote neuropathological α-synuclein aggregation. Cell, 2024
  2. In vivo optogenetic manipulations of endogenous proteins reveal spatiotemporal roles of microtubule and kinesin in dendrite patterning. Sci Adv, 2024
  3. Prior Fc receptor activation primes macrophages for increased sensitivity to IgG via long-term and short-term mechanisms. Dev Cell, 2024
  4. Intracellular tau fragment droplets serve as seeds for tau fibrils. Structure, 2024
  5. Spatiotemporal Control of Inflammatory Lytic Cell Death Through Optogenetic Induction of RIPK3 Oligomerization. J Mol Biol, 2024
  6. Engineering Material Properties of Transcription Factor Condensates to Control Gene Expression in Mammalian Cells and Mice. Small, 2024
  7. Optogenetic Regulation of EphA1 RTK Activation and Signaling. bioRxiv, 2024
  8. A platform to induce and mature biomolecular condensates using chemicals and light. Nat Chem Biol, 2024
  9. Optogenetic-mediated induction and monitoring of α-synuclein aggregation in cellular models of Parkinson's disease. STAR Protoc, 2023
  10. Optogenetic Induction of Pyroptosis, Necroptosis, and Apoptosis in Mammalian Cell Lines. Bio Protoc, 2023
  11. Light-induced condensates show accumulation-prone and less dynamic properties in the nucleus compared to the cytoplasm. Spectrosc J, 2023
  12. The Opto-inflammasome in zebrafish as a tool to study cell and tissue responses to speck formation and cell death. Elife, 2023
  13. Structural basis of NINJ1-mediated plasma membrane rupture in cell death. Nature, 2023
  14. Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics. iScience, 2023
  15. DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling. Cell Rep, 2023
  16. Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles. Nat Commun, 2022
  17. WNK kinases sense molecular crowding and rescue cell volume via phase separation. Cell, 2022
  18. Optogenetic control of GGGGCC repeat-containing RNA phase transition. Fundam res, 2022
  19. Optogenetic manipulation of cell migration with high spatiotemporal resolution using lattice lightsheet microscopy. Commun Biol, 2022
  20. Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing. Nat Commun, 2022
  21. PPARγ phase separates with RXRα at PPREs to regulate target gene expression. Cell Discov, 2022
  22. Optogenetic activators of apoptosis, necroptosis, and pyroptosis. J Cell Biol, 2022
  23. Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae. J Vis Exp, 2022
  24. CeLINC, a fluorescence-based protein-protein interaction assay in Caenorhabditis elegans. Genetics, 2021
  25. Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy. Mol Cell, 2021
  26. Rac1 activation can generate untemplated, lamellar membrane ruffles. BMC Biol, 2021
  27. Optogenetic manipulation of cellular communication using engineered myosin motors. Nat Cell Biol, 2021
  28. The proline-rich domain promotes Tau liquid-liquid phase separation in cells. J Cell Biol, 2020
  29. Nucleated transcriptional condensates amplify gene expression. Nat Cell Biol, 2020
  30. Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo. Neurobiol Dis, 2020
  31. Phosphofructokinase Relocalizes into Subcellular Compartments with Liquid-like Properties In Vivo. Biophys J, 2020
  32. m6A-binding YTHDF proteins promote stress granule formation. Nat Chem Biol, 2020
  33. Composition-dependent thermodynamics of intracellular phase separation. Nature, 2020
  34. Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering. Sci Adv, 2020
  35. Optogenetic manipulation of calcium signals in single T cells in vivo. Nat Commun, 2020
  36. Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons. Nat Commun, 2020
  37. Non-invasive optical control of endogenous Ca2+ channels in awake mice. Nat Commun, 2020
  38. Optogenetic inhibition of Delta reveals digital Notch signaling output during tissue differentiation. EMBO Rep, 2019
  39. Controlling the material properties and rRNA processing function of the nucleolus using light. Proc Natl Acad Sci USA, 2019
  40. Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments. EMBO J, 2019
  41. LADL: light-activated dynamic looping for endogenous gene expression control. Nat Methods, 2019
  42. Light-based control of metabolic flux through assembly of synthetic organelles. Nat Chem Biol, 2019
  43. NF-κB signaling dynamics is controlled by a dose-sensing autoregulatory loop. Sci Signal, 2019
  44. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron, 2019
  45. Light-Induced Protein Clustering for Optogenetic Interference and Protein Interaction Analysis in Drosophila S2 Cells. Biomolecules, 2019
  46. Increasing spatial resolution of photoregulated GTPases through immobilized peripheral membrane proteins. Small GTPases, 2018
  47. Activation of EphB2 Forward Signaling Enhances Memory Consolidation. Cell Rep, 2018
  48. Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase. Neuron, 2018
  49. Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep, 2018
  50. Optogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase. Biol Open, 2017
  51. Understanding CRY2 interactions for optical control of intracellular signaling. Nat Commun, 2017
  52. Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2. Nat Commun, 2017
  53. Optogenetic control of the Dab1 signaling pathway. Sci Rep, 2017
  54. Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets. Cell, 2016
  55. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun, 2014
  56. Arrhythmogenic properties of thiamylal sodium in the dog. J Am Vet Med Assoc, 1976
  57. Hydrolysis of aryl beta-D-glucopyranosides and beta-D-xylopyranosides by an induced beta-D-glucosidase from Stachybotrys atra. Eur J Biochem, 1979