Optogenetic Switches
UV
Violet
Blue
Cyan
Green
Yellow
Red
Far Red
300 nm
400 nm
500 nm
600 nm
700 nm
- UV receptors
- Cyanobacteriochromes
- BLUF domains
- LOV domains
- Cryptochromes
- Fluorescent proteins
- Cobalamin-binding domains
- Phytochromes
UV receptors
- Switch name (# of implementations)
- Mode of action
- UVR8/COP1 (4)
- heterodimerization
- UVR8/UVR8 (3)
- homodimerization, dissociation
Cyanobacteriochromes
- Switch name (# of implementations)
- Mode of action
- Am1 c0023g2 (0)
- not a switch, only parental photoreceptor
- Am1 c0023g2/BAm green (2)
- heterodimerization
- Am1 c0023g2/BAm red (2)
- heterodimerization
- CcaS/CcaR (33)
- gene expression
- cPAC (1)
- cAMP production
- UirS/UirR (2)
- gene expression
BLUF domains
- Switch name (# of implementations)
- Mode of action
- PixD/PixE (4)
- heterooligomerization, dissociation
LOV domains
- Switch name (# of implementations)
- Mode of action
- AsLOV2 (173)
- intramolecular conformational change
- iLID (139)
- heterodimerization
- LOVTRAP (46)
- heterodimerization, dissociation
- TULIP (34)
- heterodimerization
- AtLOV2 (10)
- intramolecular conformational change
- BcLOV4 (12)
- intramolecular conformational change, membrane recruitment
- cpLOV2 (5)
- intramolecular conformational change
- cpLID (1)
- heterodimerization
- cpLOVTRAP (2)
- heterodimerization, dissociation
- CrLOV1 (3)
- ? Add information
- EL222 (61)
- homodimerization, DNA binding
- FKF1/GI (10)
- heterodimerization
- NcWC1-LOV (4)
- ? Add information
- PtAU1-LOV (5)
- homodimerization
- RsLOV (7)
- homodimerization, dissociation
- VfAU1-LOV (25)
- homodimerization
- VVD (66)
- homodimerization
- Magnets (65)
- heterodimerization
- YtvA (40)
- homodimerization
- miniSOG (12)
- singlet oxygen (ROS) production
- mPAC (2)
- cAMP production
- PAL (9)
- RNA aptamer binding, translation control
Cryptochromes
- Switch name (# of implementations)
- Mode of action
- CRY2/CIB1 (290)
- heterodimerization
- CRY2/CRY2 (108)
- homooligomerization
- CRY2clust (18)
- homooligomerization
- CRY2olig (59)
- homooligomerization
Fluorescent proteins
- Switch name (# of implementations)
- Mode of action
- Dronpa145K/N (4)
- heterodimerization, dissociation
- Dronpa145N (4)
- homotetramerization, dissociation
- pdDronpa1 (8)
- homodimerization, dissociation
- PhoCl (15)
- photocleavage
- PYP (7)
- intramolecular conformational change
Cobalamin-binding domains
- Switch name (# of implementations)
- Mode of action
- MxCBD (2)
- homotetramerization, dissociation
- TtCBD (11)
- homotetramerization, dissociation
Phytochromes
- Switch name (# of implementations)
- Mode of action
- BphP1/PpsR2 (6)
- heterodimerization
- BphP1/Q-PAS1 (8)
- heterodimerization
- Cph1 (20)
- homodimerization
- DrBphP (13)
- homodimerization, dissociation
- MagRed (2)
- heterodimerization
- iLight (2)
- homodimerization
- PhyA/FHY1 & PhyA/FHL (4)
- heterodimerization
- PhyB/PIF3 & PhyB/PIF6 (88)
- heterodimerization